Mathematical modelling of chromosome replication and replicative stress. ([2014])

• Record Type: Book
• Further Information: Note: Jens Karschau.
• Authors: Karschau, Jens
• Contents: Supervisor's Foreword; Abstract; Acknowledgments; Contents; List of Publications; 1 Introduction; 1.1 The Cell Cycle; 1.2 General Principles of the DNA Replication Process; 1.3 Aims of This Thesis; 1.4 Origin Licensing; 1.5 Origin Firing During DNA Synthesis; 1.6 Replication Timing, Origin Positioning, and the Random Completion Problem; 1.7 Mathematical Modelling of DNA Replication; 1.8 The Spatio-Temporal Organisation of Replication Forks; References; 2 Optimal Origin Placement for Minimal Replication Time; [DELETE]; 2.1 Properties of Origins of Replication in Saccharomyces cerevisiae. 2.2 A Mathematical Model for Optimal Origin Positions2.2.1 A Simplified Two Origin Model; 2.2.2 Many Origin Loci; 2.2.3 Evolutionary Pressure Drives Yeast Origin Loci to Optimal Positions; 2.2.4 Loci Competence and Circular Chromosomes; 2.3 Optimal Origin Loci and Stochasticity in Origin Activation Time; 2.4 Summary; References; 3 Actively Replicating Domains Randomly Associate into Replication Factories; [DELETE]; 3.1 Summary of Experimental Procedure; 3.2 The Diffusion Time Scale of Two Replicating Dots; 3.3 Binding Energy; 3.4 Test of the Analytical Result Versus Computer Simulations. 3.5 Fit to Experimental Data of Replisome Association3.6 Genome-Wide Replication Data and the Number of Forks Per Factory; 3.7 Summary; References; 4 Summary and Conclusions; [DELETE].
• Publisher Details: Cham : Springer
• Publication Date: 2014
• Copyright Date: 2015
• Extent: 1 online resource (xiii, 76 pages), illustrations (some color)
• Subjects: 572.8/645; Physics; DNA replication -- Mathematical models; SCIENCE -- Life Sciences -- Biochemistry; DNA replication; Physics; Science -- Physics; Science -- Life Sciences -- Genetics & Genomics; Science -- Mathematical Physics; Statistical physics; Biochemistry; Genetic engineering; Mathematical physics; Nucleic acids; Genetic engineering; Statistical physics; Science -- Life Sciences -- Biophysics; Biophysics; Electronic books
• Languages: English
• ISBNs: 9783319088617; 3319088610; 3319088602; 9783319088600
• Related ISBNs: 9783319088600
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed July 23, 2014).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.