Cerebrospinal fluid disorders : lifelong implications /: lifelong implications. (2018)

• Record Type: Book
• Further Information: Note: David D. Limbrick Jr., Jeffrey R. Leonard, editors.
• Editors: Limbrick., David D; Leonard, Jeffrey R
• Contents: Intro; Preface; Contents; Contributors; Part I: Normal and Abnormal CSF Physiology; 1: Physiopathology of Foetal Onset Hydrocephalus; Balanced View of CSF Physiology; Aiming to a Balanced View of CSF Physiology; The CSF as a Pathway for a Cross Talk Between Different Periventricular Regions; Changing of CSF Composition as It Moves Through the Ventricular System; Multiciliated Ependyma and CSF Flow; Human Ependymogenesis; The Wall of the Lateral Ventricles of the Human Developing Brain Is a Complex and Dynamic Mosaic; Cell Types of the VZ. Evidence for an Ependymogenesis Program; Hydrocephalus A ConceptPrenatal Neurogenesis. Timetable of Neural Proliferation and Migration, Gliogenesis, and Ependymogenesis; Brain Damage Versus Brain Defects; Ventricular Zone Disruption; A Concept and Definitions; A Stormy Intracellular Traffic of Junction Proteins in NSC and Ependymal Cells Leads to Ventricular Zone Disruption; Temporal and Spatial Programs of VZ Disruption; Pathophysiology of Foetal Onset Hydrocephalus; The Complex Cell Organization of the Walls of the Sylvius Aqueduct Ventricular Zone Disruption in the Sylvius Aqueduct, Aqueduct Stenosis/Obliteration, and Noncommunicating HydrocephalusVentricular Zone Disruption in the Sylvius Aqueduct, Loss of Multiciliated Ependyma and Communicating Hydrocephalus; At Late Gestational Stages, the Disruption in the Ventricular Zone of the Telencephalon Leads to the Loss of Multiciliated Cells and Likely Alterations in the Laminar CSF Flow; Abnormal Neurogenesis Linked to Foetal Onset Hydrocephalus; Disruption of the Ventricular Zone of the Telencephalon Is Associated to Abnormal Neurogenesis The Cerebrospinal Fluid Is the Main Fate of the Disrupting NSC/NPCRepair Mechanisms of the Disrupted Ventricular Zone; Cell Therapy in the Horizon; References; 2: Iron and Hydrocephalus; Introduction; Iron Homeostasis in the Brain; Non-heme-Bound Iron; Regulation of Iron Homeostasis; Heme-Bound Iron; Underlying Chemistry of Iron-Mediated Damage; Mechanisms of Iron Toxicity; How Does Iron Induce Hydrocephalus after ICH/IVH?; How Does Iron Induce Hydrocephalus after SAH?; Animal Models; Preclinical Treatments Focusing on Iron; Deferoxamine; Minocycline Clinical Trials of Iron-Centered TreatmentsReferences; 3: Cerebrospinal Fluid Biomarkers of Hydrocephalus; Introduction; Pathophysiological Basis of CSF Biomarkers in Hydrocephalus; Methodological Approaches to CSF Biomarkers; CSF Biomarkers of Hydrocephalus; Post-hemorrhagic Hydrocephalus; Congenital Hydrocephalus; Spina Bifida-Associated Hydrocephalus; Normal Pressure Hydrocephalus; Common Pathways of CSF Biomarkers in Hydrocephalus; Challenges in CSF Biomarker Investigation in Hydrocephalus; Current Approaches to Improve Generalizability; References
• Publisher Details: Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource, illustrations (some color)
• Subjects: 616.8; Medicine; Intracranial hypertension; Central nervous system -- Diseases; Cerebrospinal fluid -- Physiology; Cerebrospinal fluid shunts; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Medical -- Family & General Practice; Medical -- Neurology; General practice; Neurology & clinical neurophysiology; Neurosurgery; Emergency medicine; Neurology; Medical -- Surgery -- Neurosurgery; Neurosurgery; Electronic books
• Languages: English
• ISBNs: 9783319979281; 3319979280
• Related ISBNs: 9783319979274; 3319979272
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed November 14, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.