Acute neuronal injury : the role of excitotoxic programmed cell death mechanisms /: the role of excitotoxic programmed cell death mechanisms. ([2018])

• Record Type: Book
• Further Information: Note: Denson G. Fujikawa, editor.
• Editors: Fujikawa, Denson G
• Contents: Intro; Dedication; Introduction; Contents; Part I: General Considerations; Chapter 1: Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms; 1.1 Introduction; 1.2 Excitotoxicity; 1.3 Role of PARP-1 and PAR Polymer in Excitotoxicity; 1.4 Role of PARG in Excitotoxicity and PAR-Mediated Cell Death; 1.5 Mitochondria in PAR-Induced Cell Death: Role of AIF and Hexokinase; 1.6 Parthanatos Associated AIF Nuclease (PAAN); 1.7 Conclusion; References; Chapter 2: To Survive or to Die: How Neurons Deal with it; 2.1 Introduction; 2.2 Calpains and NMDA Receptors 2.3 Calpain-1 Activation and Neuroprotection2.4 Calpain-2 and Neurodegeneration; 2.5 Clinical Implications of Specific Calpain-2 Inhibition and Calpain-1 Activation; References; Part II: Traumatic Brain Injury; Chapter 3: Oxidative Damage Mechanisms in Traumatic Brain Injury and Antioxidant Neuroprotective Approaches; 3.1 Introduction; 3.2 Reactive Oxygen Species and Reactive Nitrogen Species; 3.3 Lipid Peroxidation; 3.4 Free Radical-Induced Protein Carbonylation and Nitration; 3.5 Interaction of Oxidative Damage with Other Secondary Injury Mechanisms Chapter 5: Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury5.1 Introduction; 5.2 Programmed Cell Death; 5.2.1 Apoptosis; 5.2.2 Autophagy; 5.2.3 Necroptosis; 5.2.4 Interactions Between Autophagy, Apoptosis and Necroptosis; 5.3 Mechanism-Based Preclinical Pharmacological Intervention; 5.3.1 Membrane-Resealing Agents; 5.3.2 Anti-Necroptosis Agents; 5.3.3 Anti-Inflammatory Agents; 5.3.4 Mitochondrial Protective Agents; 5.3.5 Hydrogen Sulfide (H2S); 5.3.6 Others: Cathepsin B Inhibitor (CBI), and Humanin; 5.4 Conclusions and Perspective
• Edition: Second edition
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource, illustrations
• Subjects: 616.807; Medicine; Nervous system -- Diseases -- Cytopathology; Cell death; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Cell death; Medical -- Neurology; Medical -- Pathology; Science -- Life Sciences -- Biology -- Molecular Biology; Science -- Life Sciences -- Zoology -- General; Medical -- Psychiatry -- General; Neurology & clinical neurophysiology; Pathology; Cellular biology (cytology); Neurosciences; Psychiatry; Neurosciences; Neurology; Pathology; Cytology; Neurobiology; Psychiatry; Medical -- Neuroscience; Electronic books
• Languages: English
• ISBNs: 9783319774954; 3319774956
• Related ISBNs: 9783319774947; 3319774948
• Notes: Note: Includes bibliographical references.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.