Myasthenia gravis and related disorders. (2018)

• Record Type: Book
• Further Information: Note: Henry J. Kaminski, Linda L. Kushner, editors.
• Editors: Kaminski, Henry J; Kushner, Linda L
• Contents: Intro; Series Editor's Introduction; Preface; Contents; Contributors; 1: Neuromuscular Junction Physiology and Pathophysiology; Introduction; Structural Composition of the Neuromuscular Junction; The Presynaptic Compartment; The Synaptic Cleft; The Postsynaptic Compartment; Normal and Pathological Electrophysiology at the Neuromuscular Junction; Presynaptic Functional Events; Postsynaptic Functional Events; References; 2: Acetylcholine Receptor Structure; Introduction; Size and Shape of AChRs; Structures of AChR Subunits; Organization of Subunits in AChR Subtypes; Acetylcholine-Binding Sites Cation Channel and Its GateAntigenic Structure and the Main Immunogenic Region (MIR); Induction of the Autoimmune Response to AChRs in MG; Autoimmune Mechanisms Which Impair Neuromuscular Transmission in MG and EAMG; Effects of AChR Mutations in Congenital Myasthenic Syndromes; Neuronal AChR Subtypes and Functional Roles; Autoimmune Impairment of Neuronal AChRs; Effects of Human Neuronal AChR Mutations; References; 3: Immunopathogenesis of Myasthenia Gravis; Introduction; Heterogeneity of Myasthenia Gravis; Targets of the Autoimmune Response; Typical Features of MG Subtypes; AChR-MG MuSK-MG PatientsLRP4-MG Patients; Other Targets; Thymus Pathology; Thymomas; Thymic Follicular Hyperplasia; Effects of Thymectomy; Dysregulation of the Immune System; The Role of B Cells; Treg and Th17 Cells; Follicular Helper T Cells; What Are the Causes of MG?; Contribution of Genetics; Role of the MicroRNA; Triggering Factors; References; 4: Animal Models of Myasthenia Gravis for Preclinical Evaluation; Anti-AChR-Experimental Autoimmune MG (AChR-EAMG); Classical EAMG Mouse Model; Classical AChR-EAMG Rat Model: Induction; Outcome Measurements for AChR-­EAMG Models; Health Score Anti-AChR Antibody MeasurementMeasurement of Muscle AChR Concentration; Muscle Histopathology; Electromyography; Acetylcholine Receptor Antibody- Specific Passive Transfer MG (AChR-PTMG); Outcome Measurements for AChR-PTMG; Experimental Humanized Mouse Model (MG-NSG); MG-NSG Protocol; Outcome Measurements for MG-NSG; Health Score; Human Anti-AChR Antibody Measurement; Measurement of Muscle AChR Concentration; Animal Models of MuSK Myasthenia; Active Immunization Models of MuSK Myasthenia (MuSK-EAMG); Passive IgG Transfer Mouse Model of MuSK Myasthenia (MuSK-PTMG) Outcome Measurements for Rodent Models of MuSK MyastheniaAnimal Care; Rigor of Study Design; References; 5: Epidemiology and Genetics of Myasthenia Gravis; Introduction; Epidemiology of MG; Epidemiology of Antigen Subtypes; AChR Antibody-Positive MG (AChR-MG); MuSK Antibody-Positive MG; LRP4 Antibody-Positive MG; Triple-Seronegative MG (AChR-/MuSK-/LRP4-Antibody Negative); Epidemiology of Clinical Subtypes of MG; Ocular MG; Generalized MG; Thymoma-Associated MG; Treatment-Resistant Ophthalmoplegia; Genetics of Myasthenia Gravis; Non-HLA Genes
• Edition: Third edition
• Publisher Details: Cham : Humana Press
• Publication Date: 2018
• Extent: 1 online resource, illustrations (some color)
• Subjects: 616.7/442; Medicine; Myasthenia gravis -- Pathophysiology; Myoneural junction; Neuromuscular diseases -- Pathophysiology; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Myoneural junction; Medical -- Neuroscience; Medical -- Immunology; Medical -- Pulmonary & Thoracic Medicine; Neurosciences; Immunology; Respiratory medicine; Neurology; Neurosciences; Immunology; Pneumology; Medical -- Neurology; Neurology & clinical neurophysiology; Electronic books
• Languages: English
• ISBNs: 9783319735856; 3319735853
• Related ISBNs: 9783319735849
• Notes: Note: Includes bibliographical references and index.; Note: Online resource ; title from PDF title page (EBSCO, viewed March 19, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.