Nuclear pore complexes in genome organization, function and maintenance. (2018)

• Record Type: Book
• Further Information: Note: Maximiliano D'Angelo, editor.
• Editors: D'Angelo, Maximiliano
• Contents: Intro; Preface; Contents; 1 Spatial Organization of the Nucleus Compartmentalizes and Regulates the Genome; 1.1 Introduction; 1.2 Subdomains of the Nucleus; 1.2.1 Nuclear Envelope; 1.2.2 Nuclear Pore Complexes; 1.2.3 Chromosomes; 1.2.4 Centromeres; 1.2.5 Telomeres; 1.2.6 Nucleolus; 1.2.7 Perinucleolar Compartment; 1.2.8 Cajal Bodies; 1.2.9 Gemini of Coiled Bodies; 1.2.10 PML/ND10 Bodies; 1.2.11 Speckles; 1.2.12 Paraspeckles; 1.2.13 Histone Bodies; 1.2.14 Polycomb Bodies; 1.3 Composition of Nuclear Structures; 1.3.1 Mass Spectrometry Opens a Whole New Dimension in Defining Nuclear Subdomains. 1.4 Self-Assembly of Nuclear Structures1.5 Genome Organization Patterns; 1.5.1 Loops and Topologically-Associated Domains; 1.5.2 Compartments; 1.6 Structure-Function Relationships; 1.6.1 Layers of Functional Separation; 1.6.2 Loops; 1.6.3 Scaffolds; 1.6.4 Boundary Elements; 1.7 General versus Tissue- or State-Specific Functions; 1.8 Conclusions and Open Questions; 1.8.1 Mechanism for Establishment and Function of Different Organizational Patterns; 1.8.2 Zip Codes and Dynamics; 1.8.3 Conclusions; References. 2 The Molecular Composition and Function of the Nuclear Periphery and Its Impact on the Genome2.1 The Conservation of the Spatial Positioning of the Genome Across Eukaryotes; 2.2 Integral INM Proteins; 2.3 A Brief History of INM Targeting; 2.4 The Nuclear Lamina; 2.5 Lamina Associated Domains; 2.6 LADs as Developmentally Regulated Regions; 2.7 Histone Modifications at the Nuclear Periphery; 2.8 Peripheral Tethers; 2.9 Lamina Associated Sequences; 2.10 Beyond Silencing: The Periphery and Genome Integrity; 2.11 Repetitive DNA and the Nuclear Periphery. 2.12 Inputs of Nuclear Compartmentalization on DNA Repair Mechanisms2.13 Outlook; References; 3 Nuclear Pore Complexes: Fascinating Nucleocytoplasmic Checkpoints; 3.1 Introduction; 3.2 Versatility of the NPCs Structural Configuration; 3.3 Composition, Heterogeneity and Dynamics of the NPCs; 3.4 NPCs as Fascinating Gatekeepers Between the Cytoplasm and the Nucleus; 3.5 Configuration and Functional Mechanisms of the Selective NPC Barrier: FG-Nups; References; 4 Nuclear Pore Complex in Genome Organization and Gene Expression in Yeast; 4.1 Introduction. 4.2 Spatial Organization of the Yeast Genome4.3 Composition of NPC; 4.4 Nuclear Pore Complex Interacts with the Genome; 4.5 Nups Influence Transcription; 4.6 Mechanisms of Gene Recruitment; 4.7 Interchromosomal Clustering at the NPC; 4.8 Regulation of Gene Recruitment and Clustering; 4.9 Gene Recruitment and Clustering Through the Cell Cycle; 4.10 Transcription Memory; 4.11 Molecular Mechanism of INO1 Transcriptional Memory; 4.12 Concluding Remarks; References; 5 Nuclear Pore and Genome Organization and Gene Expression in Drosophila; 5.1 Introduction.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource (viii, 240 pages), color illustrations
• Subjects: 571.6/6; Medicine; Eukaryotic cells -- Genetics; Cell nuclei; SCIENCE -- Life Sciences -- Anatomy & Physiology; Cell nuclei; Eukaryotic cells -- Genetics; Medical -- Genetics; Science -- Life Sciences -- Biology -- Molecular Biology; Medical genetics; Cellular biology (cytology); Medical genetics; Gene expression; Cytology; Electronic books
• Languages: English
• ISBNs: 9783319716145
• Related ISBNs: 331971614X; 9783319716121; 3319716123
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed February 7, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.