Precision molecular pathology of prostate cancer. (2018)

• Record Type: Book
• Further Information: Note: Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors.
• Editors: Robinson, Brian D; Mosquera, Juan Miguel; Ro, Jae Y; Divatia, Mukul
• Contents: Intro; Contents; Editors and Contributors; Part I: General Principles; Chapter 1: Precision Medicine in Prostate Cancer: Approach to the Patient; Introduction; Precision Medicine in Prostate Cancer; Newly Diagnosed Prostate Cancer; Advanced Prostate Cancer; Initial Clinical Encounter; Family History in Prostate Disease; Informed Consent; Patient Preferences and Data Privacy; Actionability of Precision Medicine Results; Turnaround Time; Tissue for Genomic Profiling and Need for Serial Biopsies; Understanding â#x80;#x9C;Precision Medicine Reportsâ#x80;#x9D. Communicating Genomic Information to Clinicians and PatientsUnique Issues Related to Incidental Discovery of Germline Mutations; Future Direction; Resources for Patients and Clinicians; References; Chapter 2: Epidemiology and Etiology; Introduction: Incidence and Mortality; Etiology and Risk Factors; Modifiable; Age; Family History and Genetic Alterations (Inherited and Acquired); Race and Ethnicity; Modifiable; Obesity, Exercise, Diet, and Diabetes (Metabolic); Smoking; Conclusions; References; Chapter 3: High-Grade Prostatic Intraepithelial Neoplasia. Definition, Incidence and Evidence of Preneoplastic ProcessMolecular Features of HGPIN; Telomere Shortening; Cytogenetic Alterations; Overexpression of p16; c-myc Amplification and Caveolin-1 Overexpression; Dysregulation of Annexin; Glutathione-S-Transferase Gene Methylation; Mammalian Target of Rapamycin (mTOR) Pathway; MicroRNA Expression Profiles; TMPRSS2-ERG Fusion; Clinical Significance of HGPIN; References; Chapter 4: Pathology of Prostate Cancer; Introduction; Diagnosis of Prostatic Adenocarcinoma; Abnormal Architecture or Pattern of Glands; Loss of Basal Cell Layer. Nuclear AtypiaMinor Criteria That Are Helpfulâ#x80;#x94;But Not Requiredâ#x80;#x94;In the Diagnosis of Prostatic Adenocarcinoma; Intraluminal Blue-Tinged Mucin; Amorphous Pink Secretions; Crystalloids; Cytoplasmic Changes; Grading of Prostatic Adenocarcinoma; Variants of Acinar Adenocarcinoma; Variants of Non-acinar Carcinoma; Immunohistochemistry; Treatment Effect; Special Issues Related to Biopsy, TURP, and Prostatectomy Specimens; Needle Core Biopsy; Transurethral Resection of Prostate (TURP); Radical Prostatectomy; Conclusion; References; Chapter 5: Genetic Susceptibility; Introduction. Hereditary Prostate CancerBRCA1 and BRCA2 Genes; BRCA Genes and Cancer Risk; BRCA and Tumourigenesis; Poly(ADP-ribose) Polymerase 1 (PARP1); Susceptibility Genes; Androgen Receptor (AR) Gene; RNASEL Gene; TMPRSS2-ERG Gene Fusion; HOXB13; Mismatch Repair (MMR) Genes and Prostate Cancer; Lynch Syndrome; MSH2; Fanconi Anaemia; The FA Pathway; FA Genes and Prostate Cancer; DNA Adducts; Conclusion; References; Chapter 6: Racial Differences; Differences in the Epidemiology of Prostate Cancer Among Ethnicities; Incidence and Mortality Across Ethnic Populations Within the United States.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.99/4630758; Medicine; Prostate -- Cancer -- Molecular diagnosis; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Prostate -- Cancer -- Molecular diagnosis; Medical -- Oncology; Medical -- Urology; Oncology; Urology & urogenital medicine; Pathology; Oncology ; Urology; Medical -- Pathology; Pathology; Electronic books
• Languages: English
• ISBNs: 9783319640969; 3319640968
• Related ISBNs: 9783319640945; 3319640941
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.