Biomedical applications of acridines : derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /: derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases. (2017)

• Record Type: Book
• Further Information: Note: Jan Ježek, Jan Hlaváček, Jaroslav Šebestík.
• Authors: (Organic chemist), Ježek, Jan; Hlavacek, Jan, 1969-; Šebestík, Jaroslav
• Contents: Preliminary ToC1 Introduction.- References.- 2 Nomenclature.- References .- 3 Syntheses.- 3.1 Syntheses of acridine ring and its precursors.- 3.2 Acridine-peptide conjugates .- 3.3 Acridines as catalysts.- References.- 4.- Interactions of acridines with nucleic acids .- 4.1 DNA.- 4.2 DNA Quadruplexes.- 4.3 RNA.- 4.4 PNA .- 4.5 Acridine metal complexes.- 4.6 Structural aspects of nucleic acid binding.- References.- 5 Interactions with proteins.- 5.1 Interactions with nucleic acids processing proteins.- 5.1.1 Topoisomerases .- 5.1.2 Transcription factors.- 5.1.3 RecA protein.- 5.1.4 Telomerase.- 5.2 Interactions with other proteins.- 5.3 Structural aspects of acridine interactions with proteins.- References.- 6 Applications for treatment of neurodegenerative diseases.- 6.1 Alzheimer's disease.- 6.1.1 Multitargeted strategy in AD.- 6.2 Parkinson's disease.- 6.3 Prion diseases.- 6.4 Other neurodegenerative diseases.- References.- 7 Some application of selective toxicities of acridines.- 7.1 Antiprotozoal drug.- 7.2 Cancer treatment.- 7.3 Antibacterial drug.- 7.4 Pharmacokinetics and metabolism of acridine drugs.- References.- 8 Acridine on dendrimeric carriers.- 8.1 Application for drug and gene delivery.- References.- 9 Acridines used for staining.- References.- 10 Miscellaneous.- References.- 11 Conclusions and outlook .
• Publisher Details: Cham : Springer
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource (237 pages)
• Subjects: 572/.6; Chemistry; Acridine; Acridines; Medical -- Neuroscience; Medical -- Pharmacology; Science -- Life Sciences -- Biochemistry; Science -- Chemistry -- Organic; Neurology & clinical neurophysiology; Pharmacology; Proteins; Biochemistry; Biochemistry; Neurochemistry; Toxicology; Bioorganic chemistry; Nucleic acids; Science -- Chemistry -- Clinical
• Languages: English
• ISBNs: 9783319639536
• Related ISBNs: 9783319639529
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.