Precision molecular pathology of uterine cancer. (2017)

• Record Type: Book
• Further Information: Note: Michael T. Deavers, Donna M. Coffey, editors.
• Editors: Deavers, Michael T; Coffey, Donna M
• Contents: ""Contents""; ""Contributors""; ""Introduction""; ""1 Endometrial Carcinoma: Precursor Lesions and Molecular Profiles""; ""Introduction""; ""Endometrioid Carcinoma (Type 1)""; ""Precursor Lesions""; ""Uterine Serous Carcinoma (Type 2)""; ""Precursor Lesions""; ""Molecular Signature""; ""Molecular Alterations in Endometrioid Carcinoma""; ""Molecular Alterations in Serous Carcinoma""; ""Genomic Characterization of USC""; ""Conclusion""; ""References""; ""Endometrial Carcinoma""; ""2 Classification of Endometrial Carcinoma""; ""A Putative Pathogenetic Model for Endometrial Carcinoma"" ""Histopathologic Classification""""Endometrioid Adenocarcinoma""; ""Mucinous Carcinoma""; ""Serous Carcinoma""; ""Clear Cell Carcinoma""; ""Mixed Carcinoma""; ""Undifferentiated Carcinoma""; ""Neuroendocrine Tumors""; ""Staging of Endometrial Carcinoma""; ""Prognostic Factors""; ""Hereditary Endometrial Carcinoma""; ""References""; ""3 Immunohistochemical Markers in Endometrial Carcinoma""; ""Endometrial Carcinoma Versus Extramüllerian Primaries""; ""Endometrial Carcinoma Versus Other Müllerian Primaries""; ""Subtyping of Endometrial Carcinoma"" ""Endometrial Carcinoma and Lynch Syndrome""""Acknowledgements""; ""References""; ""4 Molecular Pathology of Endometrioid Adenocarcinoma""; ""Introduction""; ""PI3K/AKT Pathway""; ""PTEN""; ""PIK3CA""; ""PIK3R1 and PIK3R2""; ""ARID1A""; ""KRAS""; ""CTNNB1""; ""TP53""; ""Microsatellite Instability""; ""POLE""; ""The Cancer Genome Atlas""; ""Acknowledgement""; ""References""; ""5 The Molecular Pathology of Serous Endometrial Cancer""; ""Introduction""; ""Introduction to the Molecular Pathology of SEC""; ""TP53 Aberrations in SEC""; ""PI3K Pathway Aberrations in SEC"" ""PI3K Pathway Aberrations as Therapeutic Targets in SEC""""HER2 (ERBB2) Aberrations in SEC""; ""Î#x97;Î#x95;R2 as a Therapeutic Target in SEC""; ""FBXW7 Aberrations in SEC""; ""PPP2R1A Mutations in SEC""; ""CHD4 Mutations in SEC""; ""SPOP Mutations in SEC""; ""TAF1 Mutations in SEC""; ""Novel Clinical Trial Designs""; ""Summary and Conclusion""; ""References""; ""6 Uterine Clear Cell Carcinoma""; ""Introduction""; ""Histopathologic Features""; ""Immunophenotypic Features""; ""Genetic Features""; ""Biological Function of Immunohistochemical and Genetic Markers""; ""HNF-1β""; ""Napsin A"" ""Bax and Bcl-2""""TP53/p53""; ""ARID1A/BAF250a""; ""PPP2R1A""; ""PIK3CA""; ""PTEN""; ""Precursor Lesion and Oncogenesis""; ""Similarity and Differences of Molecular Features of Endometrial and Ovarian Clear Cell Carcinoma""; ""Conclusion and Future Directions""; ""References""; ""7 Mucinous Adenocarcinoma of the Endometrium""; ""Clinical Features""; ""Histopathologic Features""; ""Immunohistochemical Profile""; ""Differential Diagnosis""; ""Papillary Mucinous Metaplasia, a Possible Precursor of Mucinous Endometrial Adenocarcinoma""; ""Pyloric/Gastric Metaplasia of the Endometrium""
• Publisher Details: Cham : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 616.99/466; Medicine; Uterus -- Cancer; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Uterus -- Cancer; Medicine & Public Health; Pathology; Oncology; Gynecology; Medical -- Oncology; Medical -- Gynecology & Obstetrics; Oncology; Gynaecology & obstetrics; Pathology; Oncology ; Gynecology; Medical -- Pathology; Pathology; Electronic books
• Languages: English
• ISBNs: 9783319579856; 3319579851
• Related ISBNs: 9783319579832; 3319579835
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed November 3, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.