Membrane dynamics and calcium signaling. ([2017])

• Record Type: Book
• Further Information: Note: Joachim Krebs, editor.
• Editors: Krebs, J (Joachim), 1940-
• Contents: Intro; Preface; Contents; Part I: Plasma Membrane; Chapter 1: The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plas...; 1.1 Introduction; 1.2 General Properties of PMCA; 1.3 Structural Details of PMCA; 1.4 Genetic Diversity of PMCA in Health and Disease; 1.4.1 PMCA1; 1.4.2 PMCA2; 1.4.3 PMCA3; 1.4.4 PMCA4; 1.5 PMCA and Microdomains of Ca2+ Signaling; 1.6 Conclusions; References; Chapter 2: Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex; 2.1 Introduction Chapter 3: Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants3.1 Ca2+ Sensing by Isoform/Splice Variants and Multitask Ca2+ Signaling; 3.2 Structural and Regulatory Specificities of NCX Isoform/Splice Variants; 3.2.1 Coordination Chemistry Controls the Number and Affinity of Ca2+ Sites in Uniformly Folded CBDs; 3.2.2 Each CBD Domain Plays a Distinct Regulatory Role; 3.2.3 Exon Arrays Differentially Control the Tissue-Specific Regulatory Modes of NCX Variants; 3.3 Synergistic Interactions Between CBDs Control the Ca2+ Sensing Features 3.3.1 CBD12 Crystal Structures Highlight the Functional Significance of the Two-Domain Interface3.3.2 Ca2+ Dependent Rigidification Underlies Dynamic Coupling of CBDs; 3.4 Structure-Dynamic Basis for Ca2+ Evoked Decoding of Regulatory Massage; 3.5 Exon-Specific Roles in Editing the Regulatory Massage; 3.6 Conclusions; References; Part II: Endoplasmic/Sarcoplasmic Reticulum; Chapter 4: The Endoplasmic Reticulum and the Cellular Reticular Network; 4.1 Introduction; 4.2 The ER; 4.3 ER and Ca2+ Homeostasis; 4.4 ER-Plasma Membrane Connection: Store-Operated Calcium Entry 4.5 ER and Protein Quality Control4.6 ER and Cellular Stress Coping Response Strategies; 4.7 ER and Lipid Metabolism; 4.8 ER and Membrane Contact Sites; 4.9 Conclusions; References; Chapter 5: Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin; 5.1 Calcium Homeostasis; 5.2 SERCA Isoforms and Human Disease (P-Type ATPases); 5.2.1 SERCA1; 5.2.2 SERCA2; 5.2.3 SERCA3; 5.3 Catalytic Cycle of Calcium Transport by SERCA; 5.4 Structural Studies of SERCA; 5.4.1 Structural Insights into the SERCA Calcium Transport Cycle
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 572/.516; Life sciences; Calcium -- Physiological effect; Calcium channels; Cellular signal transduction; Cell membranes; Cell receptors; SCIENCE / Life Sciences / Biochemistry; Calcium channels; Calcium -- Physiological effect; Cell membranes; Cell receptors; Cellular signal transduction; Calcium Signaling; Cell Membrane -- physiology; Calcium Channels; Membrane Microdomains -- physiology; Signal Transduction; Cell Physiological Phenomena; Science -- Life Sciences -- Biochemistry; Science -- Life Sciences -- Biophysics; Proteins; Biophysics; Science -- Life Sciences -- Cytology; Cellular biology (cytology); Electronic books
• Languages: English
• ISBNs: 9783319558585; 3319558587
• Related ISBNs: 9783319558578; 3319558579
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed April 5, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.