Neuroepigenomics in aging and disease. (2017)

• Record Type: Book
• Further Information: Note: Raul Delgado-Morales, editor.
• Editors: Delgado-Morales, Raul
• Contents: Contributors; Part I: Neurodevelopmental and Childhood Disorders; 1: MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome; 1.1 Introduction; 1.2 MeCP2: The Protein; 1.3 DNA Methylation and MeCP2 Binding in the Brain; 1.4 MeCP2-Chromatin Binding; 1.5 Every Single Amino Acid Matters; 1.6 Teaming Up; 1.7 Higher-Order Chromatin Structures; 1.8 Neuronal Chromatin: Histone H1 and MeCP2; 1.9 Concluding Remarks; References; 2: The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome; 2.1 Introduction; 2.2 Rett Syndrome. 2.2.1 MeCP22.2.2 Rett Syndrome Models; 2.3 Rett Syndrome and ncRNAs; 2.3.1 ncRNAs and Therapies; 2.4 Conclusions and Future Perspectives; References; 3: Rubinstein-Taybi Syndrome and Epigenetic Alterations; 3.1 Introduction; 3.2 Genotype; 3.3 Clinical Phenotypes; 3.3.1 Epigenetic Mechanisms Underlying RSTS; 3.3.2 Testing the Biological Function of CBP in Rodents: Epigenetics and Memory; 3.3.3 Potential Therapeutic Applications of Histone Deacetylase Inhibitors for RSTS; References; 4: Epigenetics of Autism Spectrum Disorder. 4.1 Autism Spectrum Disorder (ASD) and Proposed Aetiologies4.2 Genetics of ASD; 4.3 Environmental Exposures and ASD Risk; 4.3.1 Exogenous Environment; 4.3.2 Endogenous Environment; 4.4 The Direct Role of Epigenetics in ASD; 4.4.1 Genetic Syndromes Involving Epigenes and ASD; 4.4.2 Direct Assessment of Epigenetic Marks in ASD; 4.5 Therapeutics; 4.6 Future Directions/Summary; References; Part II: Adolescence Brain Diseases; 5: Eating Disorders and Epigenetics; 5.1 Introduction; 5.2 Genetics of EDs; 5.3 Epigenetics and EDs; 5.4 Early Life Stresses. 5.5 Obstetric and Perinatal Complications5.6 Nutritional Factors and DNA Methylation; 5.7 Epigenetic Studies in ED Samples; 5.8 Conclusions and Future Directions; References; 6: Drug Addiction and DNA Modifications; 6.1 DNA Epigenetic Modifications; 6.2 Addiction; 6.3 Neuroepigenetics of Addiction; 6.3.1 Human Studies; 6.3.2 Animal Studies; 6.4 Multigenerational Effects of Drug Exposure; References; 7: Drug Addiction and Histone Code Alterations; 7.1 Introduction; 7.1.1 Epigenetics and Histone Code; 7.1.2 Histone Acetylation; 7.1.3 Histone Methylation. 7.1.4 Histone Phosphorylation7.1.5 Histone Ubiquitination and Sumoylation; 7.1.6 Other Modifications and Combinatorial Effects; 7.2 Histone Modifications and Addiction; 7.2.1 Histone Acetylation; 7.2.2 Histone Methylation; 7.2.3 Other Modifications; 7.3 Conclusions and Future Work; References; 8: Anxiety and Epigenetics; 8.1 Introduction; 8.2 The Neuroanatomy of Anxiety Disorders; 8.3 The Neuroendocrine Axis in Anxiety Disorders; 8.4 Epigenetic Factors; 8.5 Epigenetics in Animal Models of Anxiety; 8.6 Transgenerational Epigenetics.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 612.8; Life sciences; Neurogenetics; Aging -- Genetic aspects; Genetic disorders; Humans; Aging -- genetics; Epigenomics; Nervous System Diseases -- genetics; MEDICAL -- Physiology; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Aging -- Genetic aspects; Genetic disorders; Neurogenetics; Medical -- Genetics; Medical genetics; Proteomics; Gene expression; Medical genetics; Science -- Life Sciences -- Biochemistry; Proteins; Electronic books
• Languages: English
• ISBNs: 9783319538891; 3319538896
• Related ISBNs: 9783319538884; 3319538888
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed May 24, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.