Safety and efficacy of gene-based therapeutics for inherited disorders. ([2017])

• Record Type: Book
• Further Information: Note: Nicola Brunetti-Pierri, editor.
• Editors: Brunetti-Pierri, Nicola
• Contents: Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource
• Subjects: 616.042; Medicine; Genetic disorders -- Gene therapy; Genetic transformation; Genetic Diseases, Inborn -- therapy; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Genetic transformation; Medical -- Genetics; Science -- Life Sciences -- Biology -- Molecular Biology; Medical genetics; Medical research; Toxicology; Gene therapy; Medical -- Pharmacology; Pharmacology; Electronic books
• Languages: English
• ISBNs: 9783319534572; 3319534572; 3319534556; 9783319534558
• Related ISBNs: 9783319534558
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed June 6, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.