Reviews of physiology, biochemistry and pharmacology. 172 (2016)

• Record Type: Book
• Further Information: Note: Edited by Bernd Nilius, Pieter de Tombe, Thomas Gudermann, Reinhard Jahn, Roland Lill, Ole H. Petersen.
• Editors: Nilius, B; Tombe, Pieter de; Gudermann, Thomas; Jahn, Reinhard, 1950-; Lill, Roland; Petersen, Ole
• Contents: Hepatic Stellate Cells in Liver Fibrosis and siRNA-Based Therapy; 1 Introduction; 2 Hepatic Stellate Cells; 2.1 Functions of HSC in the Normal and in the Injured Liver; 2.1.1 Storage of Vitamin A; 2.1.2 Extracellular Matrix (ECM) Synthesis and Degradation; 2.1.3 Liver Development and Regeneration; 2.1.4 Immunoregulation Function; 2.2 HSC and Liver Fibrosis; 3 Resolution of Fibrosis; 3.1 Anti-fibrotic Therapeutic Approaches; 3.2 Gene Therapy; 3.3 RNA Interference; 3.3.1 Barriers of siRNA Delivery and Therapy; 4 Lipid-Based siRNA Delivery; 4.1 Cationic Liposomes; 4.2 Neutral Lipids 4.3 Stable Nucleic Acid-Lipid Particles (SNALPs)5 Polymeric Nanoparticles; 5.1 Polyethyleneimine; 5.2 Poly(Lactic-co-Glycolic Acid) (PLGA); 5.3 Chitosan; 5.4 Cyclodextrin; 6 SiRNA-Nanotherapeutics and Liver Fibrosis; 7 Conclusion; References; Exosomes: From Functions in Host-Pathogen Interactions and Immunity to Diagnostic and Therapeutic Opportunities; 1 Introduction; 2 Exosome Biogenesis and Secretion; 3 Exosome Molecular Composition; 4 Exosome as Immunomodulators; 4.1 Exosomes and Innate Immunity; 4.2 Exosomes and Acquired Immunity; 5 Exosomes in Host-Pathogen Interactions 5.1 Exosomes in Fungal Infection5.2 Exosomes in Parasitic Infection; 5.3 Exosomes in Viral Infection; 5.4 Exosomes in Bacterial Infection; 6 Exosomes in Disease States: Applications in Diagnostic, Vaccine, and Therapeutic Approaches; 6.1 Exosomes: Promising Diagnostic Tools; 6.2 Exosome-Based Vaccination: An Encouraging Approach; 6.3 Exosomes: Promising New Conveyors of Therapeutic Molecules; 7 Conclusion; References; The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias; 1 Introduction; 2 Electrical Remodeling and Arrhythmia Development; 3 Excitation-Contraction Coupling 4 Arrhythmia Initiation and Abnormal Ca2+ Triggered Activities5 Arrhythmia Stabilization; 6 MAPKs and Arrhythmia Development; 7 MAPKs Activation and Pathological Remodeling in the Heart; 8 MAPK Family; 9 Conclusions and Implications; References
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 612; 610; Medicine; Human physiology; Molecular biology; Metabolism -- Disorders; MEDICAL / Physiology; SCIENCE / Life Sciences / Human Anatomy & Physiology; Human physiology; Metabolism -- Disorders; Molecular biology; Medical -- Pharmacy; Medical -- Gastroenterology; Medical -- Microbiology; Medical -- Infectious Diseases; Medical -- Cardiology; Pharmaceutical technology; Hepatology; Medical microbiology & virology; Infectious & contagious diseases; Cardiovascular medicine; Immunology; Pharmaceutical technology; Clinical medicine; Medical virology; Emerging infectious diseases; Cardiology; Medical -- Immunology; Immunology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319499024; 3319499025; 3319499017; 9783319499017
• Related ISBNs: 9783319499017
• Notes: Note: Includes bibliographical references at the end of each chapters.; Note: Online resource; title from PDF title page (SpringerLink, viewed January 5, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.