Immunotherapy of melanoma. (2016)

• Record Type: Book
• Further Information: Note: Anand Rotte, Madhuri Bhandaru.
• Other Names: Rotte, Anand; Bhandaru, Madhuri
• Contents: Melanoma; 1 Melanoma-Introduction, History and Epidemiology; Abstract; 1.1 Introduction; 1.1.1 Basics of Structure and Functions of Skin; 1.1.2 Melanocytes; 1.1.3 Melanoma-Definition; 1.1.4 Prominent People Who Were Diagnosed with Melanoma; 1.2 History; 1.2.1 Initial Descriptions of Melanoma; 1.2.2 Hereditary Nature of Melanoma; 1.2.3 Descriptions of Uveal Melanoma; 1.2.4 Introduction of Term 'Melanoma'; 1.2.5 Descriptions of Association Between Melanoma and Skin Color; 1.2.6 Introduction of Clark's Level and Breslow Thickness. 1.2.7 Descriptions of Associations Between Sunlight, MC1R Mutations and Melanoma1.2.8 Description of Familial Atypical Multiple Mole Melanoma and CDKN2A Mutations; 1.2.9 Discovery of Ras Oncogenes and Their Relationship with Melanoma; 1.2.9.1 Epidemiology; References; 2 Melanoma-Diagnosis, Subtypes and AJCC Stages; Abstract; 2.1 Introduction; 2.2 Signs and Symptoms of Melanoma; 2.3 Diagnosis; 2.3.1 Dermoscopy; 2.3.2 Total-Body Photography; 2.3.3 In Vivo Reflectance Confocal Laser Microscopy; 2.3.4 Histopathology; 2.3.5 Molecular Diagnosis; 2.4 Types of Melanoma. 2.4.1 Superficial Spreading Melanoma2.4.2 Lentigo Maligna Melanoma; 2.4.3 Acral Lentiginous Melanoma; 2.4.4 Nodular Melanoma; 2.4.5 Desmoplastic Melanoma; 2.4.6 Nevoid Melanoma; 2.4.7 Verrucous Melanoma; 2.5 Melanoma Stages; 2.5.1 Clark Classification; 2.5.2 Breslow Classification; 2.5.3 TNM (Tumor, Node and Metastasis) Classification; 2.5.4 Melanoma Staging-AJCC System; References; 3 Etiology; Abstract; 3.1 Introduction; 3.2 UV Light and Sun Exposure; 3.2.1 Sunlight Exposure and DNA Damage; 3.2.2 Repair of UV Induced DNA Damage; 3.2.3 Xeroderma Pigmentosum; 3.3 Family History. 3.4 Familial Atypical Multiple Mole Melanoma Syndrome3.5 Skin and Hair Color; 3.6 Susceptibility Genes; 3.6.1 Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A); 3.6.2 Cyclin Dependent Kinase 4 (CDK4); 3.6.3 Melanocortin 1 Receptor (MC1R); 3.6.4 Microphthalmia-associated Transcription Factor (MITF); 3.7 Aberrant Signaling Pathways; 3.7.1 c-KIT or KIT; 3.7.2 RAS Family of Proteins; 3.7.3 BRAF Activation; References; 4 Melanoma-Treatment; Abstract; 4.1 Evolution of Treatment in 19th and 20th Centuries; 4.2 Surgery; 4.2.1 Primary Melanoma; 4.2.2 Regional Lymph Node Metastasis. 4.2.3 Metastatic Melanoma4.3 Adjuvant Therapy; 4.3.1 Adjuvant Immunotherapy; 4.3.2 Adjuvant Radiation Therapy; 4.4 Chemotherapy; 4.4.1 Alkylating Agents (Dacarbazine/Temozolomide); 4.4.2 Biochemotherapy; 4.5 Targeted Therapy; 4.5.1 BRAFV600E Inhibitors; 4.5.2 MEK Inhibitors; 4.6 Immunotherapy; 4.7 Recommendations (2013)€from Society of Immunotherapy of Cancer for Stage IV Melanoma; References; Tumor Immunology; 5 Overview of Immune System; Abstract; 5.1 Introduction; 5.2 Innate Immune System; 5.2.1 Neutrophils; 5.2.2 Complement System; 5.2.3 Eosinophils; 5.2.4 Mast Cells.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 616.99/47706; 610; Medicine; Melanoma -- Immunotherapy; Melanoma -- Immunological aspects; Cancer -- Research; Oncology; Melanoma -- therapy; HEALTH & FITNESS -- Holism; HEALTH & FITNESS -- Reference; MEDICAL -- Alternative Medicine; MEDICAL -- Atlases; MEDICAL -- Essays; MEDICAL -- Family & General Practice; MEDICAL -- Holistic Medicine; MEDICAL -- Osteopathy; Melanoma -- Immunological aspects; Cancer -- Research; Medicine; Oncology; Biomedicine; Cancer Research; Oncology; Medical -- Oncology; Oncology; Oncology ; Electronic books
• Languages: English
• ISBNs: 9783319480664; 3319480669; 3319480650; 9783319480657
• Related ISBNs: 9783319480657
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed February 2, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.