Bone morphogenetic proteins : systems biology regulators /: systems biology regulators. (2017)

• Record Type: Book
• Further Information: Note: Slobodan Vukicevic, Kuber T. Sampath, editors.
• Editors: Vukicevic, Slobodan, 1951-; Sampath, Kuber T
• Contents: Preface; Contents; List of Contributors; Historical Perspective of€Bone Morphogenetic Proteins; 1 Bone Formation: Auto-induction; 2 Matrix-Induced Bone Formation: A€Biological Cascade; 3 Discovery of€Bone Morphogenetic Proteins; 4 BMP Structure; 5 BMP Receptors; 6 BMP Preclinical Studies; 7 BMP-7 in€Articular Cartilage Repair; 8 BMPs Beyond Bone; 9 BMP Clinical Studies; 10 Conclusion; References; The Systems Biology of€Bone Morphogenetic Proteins; 1 BMPs During Development; 2 Structure and€Function; 3 BMP: In€Vitro and€In€Vivo Model Systems for€Endochondral Bone Differentiation. 4 Role of€BMPs in€Cartilage Repair and€Regeneration5 Role of€BMPs in€Bone Repair and€Regeneration; 6 BMPs in€Dentin Repair and€Regeneration; 7 BMP-7 in€Acute and€Chronic Kidney Failure; 8 BMPs in€Glucose Homeostasis; 9 BMP-7 and€Calcium and€Phosphate Homeostasis; 10 BMPs in€Iron Homeostasis; 11 BMPs' Role in€Rare Genetic Disorders; 12 BMP in€Oncology; 13 Conclusion; References; Embryonic Skeletogenesis and€Craniofacial Development; 1 Introduction; 2 Embryonic Skeletogenesis; 2.1 Developmental Stages of€Ossification; 2.2 BMP and€Osteogenesis; 2.3 Functional Studies in€Animal Models. 2.3.1 BMP and€Osteoblasts2.3.2 BMP and€Chondrocytes; 2.3.3 BMP and€Mesenchymal Cells; 2.3.4 BMP and€Osteoclasts; 2.3.5 BMP and€Other Cell Types in€Skeletal System; 2.4 BMP and€Bone-Related Diseases; 3 Craniofacial Development; 3.1 Head Induction; 3.2 Facial Development and€Abnormalities; 3.2.1 BMP and€Cleft Lip; 3.2.2 BMP, Facial Cleft, and€Midline Structure; 3.2.3 BMP and€Cleft Palate; 3.3 Calvarial Vault and€Cranial Base; 3.3.1 BMP and€Skull Formation; 3.3.2 BMP and€Suture Formation; 3.3.3 BMP and€Cranial Base; 3.4 Mandibular Development and€Temporomandibular Joint Formation. 3.4.1 BMP and€Mandible3.4.2 BMP and€the€Temporomandibular Joint; 4 Perspective and€Conclusions; References; BMP and€BMP Regulation: Structure and€Function; 1 General Mechanisms for€BMP Binding to€BMP Type I€and€Type II Receptors; 2 General Mechanisms for€BMP Inhibition and€Antagonism; 3 Noggin-Mediated Antagonism; 4 Follistatin Family-Mediated Antagonism; 5 Chordin Family-Mediated Antagonism; 6 DAN Family-Mediated Antagonism; 7 Prodomain Interactions and€Latent Complex Formation; 8 Co-receptors, Signal Enhancers, and€Other Antagonists; 9 Summary of€BMP Regulation Through€Different Mechanisms.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource (xii, 445 pages), illustrations (some color)
• Subjects: 612.7/51; Medicine; Bone morphogenetic proteins; MEDICAL -- Physiology; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Bone morphogenetic proteins; Bone Morphogenetic Proteins; Biomedicine; Immunology; Cell Biology; Cytokines and Growth Factors; Protein Science; Systems Biology; Science -- Life Sciences -- Biology -- Molecular Biology; Science -- Life Sciences -- Biochemistry; Science -- Life Sciences -- General; Cellular biology (cytology); Proteins; Life sciences: general issues; Immunology; Cytology; Cytokines; Biochemistry; Biological models; Medical -- Immunology; Immunology; Electronic books
• Languages: English
• ISBNs: 9783319475073
• Related ISBNs: 331947507X; 9783319475059; 3319475053
• Notes: Note: ReferencesNovel In€Vitro Assay Models to€Study Osteogenesis and€Chondrogenesis for€Human Skeletal Disorders; 1 Phenotypic Markers of€Skeletal Tissue-Forming Cells; 1.1 Osteoblasts; 1.2 Chondrocytes; 2 C2C12 Myoblasts for€BMP/GDF Research; 2.1 C2C12 Myoblasts; 2.2 Osteoblastic Differentiation of€C2C12 Myoblasts by BMPs; 2.3 Applications of€C2C12 Myoblasts for€Signaling Molecules of€BMPs/GDFs; 2.3.1 Receptors; 2.3.2 Transcription Factors; 2.3.3 Early Response Genes of€BMP Signaling; 3 Models of€Chondrogenesis; 3.1 Skeletal Muscle Cells.; Note: Online resource; title from PDF title page (SpringerLink, viewed March 24, 2017).
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