Biochemistry of oxidative stress : physiopathology and clinical aspects /: physiopathology and clinical aspects. (2016)

• Record Type: Book
• Further Information: Note: Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso, editors.
• Editors: Gelpi, Ricardo J; Boveris, Alberto; Poderoso, Juan José
• Contents: Preface; Contents; Part I: General Aspects; Chapter 1: The Concept of Oxidative Stress After 30 Years; 1 Introduction; 2 Concept of "Oxidative Stress"; 3 The Redox Code; 4 Specific Forms of Oxidative Stress; 5 Role of Hydrogen Peroxide in Oxidative Stress and Redox Signaling; 6 Molecular Redox Switches; 7 Redox Medicine; 8 Cautionary Words; 9 Conclusions; References; Chapter 2: The Evolution of the Earth and Its Atmosphere; 1 Evolution of the Earth: Geologic Timeline; 1.1 Precambrian; 1.2 Paleozoic; 1.3 Mesozoic; 1.4 Cenozoic; 1.5 Quaternary; 2 The Origin of Mitochondria. 2.1 How Did the Mitochondrial Endo Symbiogenesis Occurred?3 Geological History of Oxygen; 3.1 Effects on Life; 4 Conclusion; References; Chapter 3: Mitochondria Are the Main Cellular Source of O2−, H2O2 and Oxidative Stress; 1 Introduction. The Partial Reduction of Oxygen and the Reactive Oxygen Species; 2 The Mitochondrial Production of O2− and H2O2; 3 Mitochondrial Function in Cell Physiology; 4 Steady States and Half Lives of Reactive Oxygen Species; 5 Oxidative Stress; 6 Physiology of the Products of the Partial Reduction of Oxygen 7 Experimental Determination of Oxidative Stress in Cells and Tissues8 Aging; 9 Conclusions; References; Chapter 4: Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase; 1 Introduction; 2 Nitric Oxide Regulates Mitochondrial Respiration and Superoxide Anion and Hydrogen Peroxide Productions; 3 Other Effects of NO and NO-Derived Species on Mitochondrial Functions; 4 Heart mtNOS Activity and Identity; 5 Regulation of Heart Mitochondrial NOS; 6 Conclusions; References; Chapter 5: Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications. 1 Introduction2 Nitric Oxide: Sources and Destination of an Ubiquitous Reactive Nitrogen Species; 2.1 Biological Formation of NO; 2.2 Fates of NO; 2.3 Autoxidation Reactions; 2.4 Reactions with Radical Species; 2.5 Reaction with Metal Centers; 3 Peroxynitrite: A Potential Harm for Multiple Biomolecules; 3.1 Biological Formation of ONOO−; 3.2 Fates of ONOO−; 3.3 Carbon Dioxide; 3.4 Thiols; 3.5 Metal Centers; 3.6 Tyrosine Residues; 3.7 DNA; 3.8 Lipids; 4 Physiology and Pathophysiology of NO and Peroxynitrite-­Derived Oxidants; 4.1 Peroxynitrite and Mitochondrial Dysfunction 4.2 Apoptosis and Necrosis4.3 Peroxynitrite, Inflammation and Immune Responses; 4.4 Reactive Nitrogen Species in the Development of Cardiovascular Disease; 4.5 Neurodegenerative Diseases and Nitroxidative Damage; 4.6 Sepsis; 4.7 Cancer; 5 Pharmacology Directed to Prevent Nitroxidative Damage; 5.1 Inhibitors of ONOO− Formation ; 5.2 Direct Antioxidants; 5.3 Catalytic Antioxidants; 5.4 Antioxidant Inducers; 6 Conclusions; References; Chapter 6: Nitro-arachidonic Acid: Downstream Signaling and Therapeutics; 1 Introduction; 2 Mechanisms of Arachidonic Acid Nitration
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 571.9/453; 610; Medicine; Oxidative stress; SCIENCE -- Life Sciences -- Anatomy & Physiology; Oxidative stress; Oxidative Stress; Science -- Life Sciences -- Cytology; Cellular biology (cytology); Oncology; Cell physiology; Cytology; Medical -- Oncology; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319458656; 3319458655; 3319458647; 9783319458649
• Related ISBNs: 9783319458649
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.