Bacteriophage applications : historical perspective and future potential /: historical perspective and future potential. (2016)

• Record Type: Book
• Further Information: Note: Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev.
• Authors: Nicastro, Jessica; Wong, Shirley; Khazaei, Zahra; Lam, Peggy; Blay, Jonathan; Slavcev, Roderick A
• Contents: 1 Overview of Bacteriophage Lifecycles and Applications; 1 Introduction; 2 Phage Infection and Life-Cycle; 2.1 Lytic Phage; 2.2 Temperate Phage; 3 Phage Infection Stages; 3.1 Phage Entry; 3.2 DNA Replication; 3.3 Phage Assembly; 3.3.1 Tailed (dsDNA) Phages; 3.3.2 ssDNA Phages; 3.3.3 ssRNA Phages; 4 Hurdles for Phage-Based Therapeutics; References; 2 Phage for Biocontrol; Abstract; 1 Introduction; 2 The Importance of Using Recombinant Phage; 3 Recombinant Phage for the Treatment of Bacterial Infections; 3.1 Escherichia coli (E. coli); 3.2 Staphylococcus aureus (S. aureus). 3.3 Chlamydia trachomatis3.4 Pseudomonas aeruginosa (PA); 3.5 Helicobacter pylori (H. pylori); 4 Phage as Drug Delivery Vehicles for the Treatment of Bacterial Infections; 5 Summary; References; 3 Phage Device Coatings; Abstract; 1 Introduction; 2 Biofilms on Medical Devices; 2.1 Contributors to Biofilm Resistance; 3 Alternative Medical Coating Devices; 4 Bacteriophage as Bioactive Coatings; 5 Conclusions; References; 4 Bacteriophages Functionalized for Gene Delivery and the Targeting of Gene Networks; Abstract; 1 Introduction to Phage Mediated Delivery of Genetic Material. 2 Bacteriophages as Gene Delivery Vehicles3 Phages as Cytotoxic Agents in Eukaryotes; 4 Phages for Delivery to the Central Nervous System; 5 Conclusions; References; 5 Phage Probiotics; Abstract; 1 Introduction: The Gut Microbiota and Probiotics; 2 Roles of the Gut Microbiota and Probiotics; 2.1 Protection Against Pathogens; 2.2 Metabolism; 2.3 Immunomodulation; 2.4 Tissue Development and Maintenance; 3 Bacteriophages in the Gut; 3.1 Phage Population Dynamics; 3.2 Protection Against Pathogens and Immunomodulation; 4 Applications of Phage; 4.1 Lytic Phage Therapy; 4.2 Phage Biotechnology. 5 ConclusionsReferences; 6 Phage for Biodetection; Abstract; 1 Introduction to Phage-Based Biodetection; 2 Plaque Assays; 2.1 Phage Display for the Improvement of Plaque Assays; 3 Bacteriophage Indicator Organisms (Reporter Phage); 3.1 Fluorescence-Based Assays; 4 Immobilized Phage Particles as Probes for Bacterial Detection; 5 Conclusions; References; 7 Phage-Mediated Immunomodulation; 1 Introduction; 2 Immune Responses to Phage; 2.1 Anti-phage Innate Responses; 2.2 Humoral Immune Reposes to Phage (Anti-phage Antibodies). 2.3 Anti-phage Cellular Immunity and the Implications of the Impact of Phage on the Adaptive Responses (T and B Cells)3 Bacteriophage-Based Immune-Pharmaco-Therapies; 3.1 Phage Immunogenicity and Cancer Therapy; 3.1.1 Phage in Tumor Targeting; 3.1.2 Anti-tumor Phage Therapies; 3.2 Bacteriophage Immunotherapy Autoimmune Disorders; 3.3 Bacteriophage Immunotherapy for Drug Addiction; 3.4 Phages and Oxidative Stress; 4 Conclusions; References.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource (vii, 82 pages)
• Subjects: 579.2/6; Chemistry; Bacteriophages; SCIENCE -- Life Sciences -- Biology; SCIENCE -- Life Sciences -- Microbiology; Bacteriophages; Science -- Life Sciences -- Biology -- Molecular Biology; Medical -- Genetics; Biochemistry; Medical genetics; Biochemical engineering; Gene libraries; Gene expression; Technology & Engineering -- Chemical & Biochemical; Biochemical engineering; Electronic books
• Languages: English
• ISBNs: 9783319457918; 3319457918; 3319457896; 9783319457895
• Related ISBNs: 9783319457895
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed October 14, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.