The blood brain barrier and inflammation. ([2017])

• Record Type: Book
• Further Information: Note: Ruth Lyck, Gaby Enzmann, editors.
• Editors: Lyck, Ruth; Enzmann, Gaby
• Contents: General Introduction to Barrier Mechanisms in the Central Nervous System; 1 Introduction; 2 Barriers of the Brain; 3 Cellular Components of the Neurovascular Unit; 4 Influx Mechanisms of the Blood-Brain Barrier; 5 Efflux Mechanisms of the Brain Barrier Interfaces; 6 Brain Barriers Regulate CSF Secretion; 7 Conclusion; References; Topological Aspects of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers and Their Relevance in Inflammation; 1 Introduction; 2 Brain Inflammation in Human Diseases and Animal Models; 2.1 Multiple Sclerosis. 2.2 An Animal Model for MS: Experimental Autoimmune Encephalomyelitis2.3 Lymphocyte Entry into the CNS; 2.4 BBB Permeability During CNS Inflammation; 2.5 Cortical Inflammation in MS; 2.6 The Two-Wave Model for Lymphocyte Entry; 2.7 Neuromyelitis Optica; 3 Topology of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; 3.1 The Endothelial Side of the Barrier; 3.2 The Glial Side of the Barriers; 3.3 Water Movements in the Brain; 4 Barrier-Related Cellular Characteristics of Epithelial Cells of the Choroid Plexus and Vascular Endothelial Cells During Inflammation; 5 Conclusions; Literature. The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions1 The Blood-Brain Barrier; 2 The Extracellular Matrix of the CNS; 3 Laminin Receptors on Endothelium and Astrocyte Endfeet; 4 Contributions of the Basement Membranes to BBB integrity; 4.1 Genetic Defects; 4.2 Autoimmune Diseases; 4.2.1 Leukocyte Transmigration Across the Endothelial BM; 4.2.2 Leukocyte Transmigration Across the Parenchymal BM; 5 Conclusion; References; Pathophysiology of the Blood-Brain Barrier in Neuroinflammatory Diseases; 1 Introduction; 2 Multiple Sclerosis. 2.1 Alzheimer's Disease3 Amyotrophic Lateral Sclerosis; 3.1 Parkinson's Disease; 3.2 Huntington's Disease; 4 Conclusion; References; Leakage at Blood-Neural Barriers; 1 Rationale; 2 Measuring Vascular Permeability; 3 Basal Water and Solute Transport at Blood-Neural Barriers; 4 Pathophysiological Leakage; 5 The Paracellular Leakage Pathway; 6 The Transcellular Leakage Pathway; 7 Endothelial Signalling During BBB or BRB Leakage; 8 BBB/BRB Function and Dysfunction: Nature and Nurture; 9 Opening the BBB for Therapeutic Drug Delivery; 10 Conclusion; References. Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology1 Introduction; 2 BBB Transporter Proteins; 2.1 ATP-Binding Cassette Transporters; 2.1.1 Subfamily A Member: CERP (ABCA1); 2.1.2 Subfamily B Member: MDR1/P-gp (ABCB1); 2.1.3 Subfamily C, Members: MRP1 (ABCC1) and MRP4 (ABCC4); 2.1.4 Subfamily G, Member BCRP (ABCG2); 2.2 Solute Carrier Transporters; 2.2.1 SLC2: Facilitative Glucose Transporter Family Member: GLUT1 (SLC2A1); 2.2.2 SLC7A-SLC3A2: Neutral Amino Acid Transporter (LAT1-4F2hc).
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource
• Subjects: 573.8/621; Medicine; Blood-brain barrier; Inflammation; SOCIAL SCIENCE -- Anthropology -- Physical; Blood-brain barrier; Inflammation; Medical -- Neuroscience; Science -- Life Sciences -- Cytology; Medical -- Infectious Diseases; Science -- Life Sciences -- Biochemistry; Neurosciences; Cellular biology (cytology); Infectious & contagious diseases; Immunology; Neurosciences; Cell membranes; Emerging infectious diseases; Cytokines; Medical -- Immunology; Immunology; Electronic books
• Languages: English
• ISBNs: 9783319455143; 3319455141
• Related ISBNs: 9783319455129; 3319455125
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed April 5, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.