Nutrigenomics. (2016)

• Record Type: Book
• Further Information: Note: Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár.
• Authors: Carlberg, Carsten; Ulven, Stine Marie; Molnár, Ferdinand
• Contents: Section A: Introduction 1. Nutrition and common diseases1.1 Human nutrition1.2 Nutrition and obesity1.3 Nutrition and cancer1.4 Nutrition and diabetes1.5 Nutrition and cardiovascular diseases1.6 Impact of exercise 2. Human genomic variation2.1 Migration and evolutionary challenges of the modern human2.2 Diversity of human populations2.3 Genetic variants of the human genome2.4 The HapMap Project and haplotype blocks2.5 Genome-wide association studies2.6 Whole genome sequencing and the 1000 Genomes Project Section B: Molecular genetic basis 3. Sensing nutrition3.1 Nutrient-sensing mechanisms3.2 Nutrient-sensing via nuclear receptors3.3 Functions and actions of PPARs3.4 Integration of lipid metabolism by LXRs and FXR3.5 Coordination of the immune response by VDR3.6 Circadian control of metabolic processes 4. Nutrigenomics: Adapting the human genome to dietary changes and personalized nutrition4.1 Definition of nutrigenomics4.2 Vitamin D and skin color4.3 Human genetic adaption to dietary changes4.4 Regulatory SNPs and quantitative traits4.5 'Omics' analysis in nutrition sciences4.6 Integrative personal omics profile 5. Nutritional epigenomics5.1 Epigenetic mechanisms5.2 Intermediary metabolism and epigenetic signaling5.3 One-carbon metabolism and DNA methylation5.4 Nutrition-triggered transgenerational epigenetics in mice5.5 Epigenetic programming in humans 6. Nutritional signaling and aging6.1 Aging and conserved nutrient-sensing pathways6.2 Neuroendocrine aging regulation in humans and other mammals6.3 Caloric restriction from yeast to mammals6.4 Properties and functions of sirtuins6.5 Cellular energy status sensing by AMPK 7. Chronic inflammation and metabolic stress7.1 Central role of monocytes and macrophages7.2 Acute and chronic inflammation7.3 Reverse cholesterol transport and inflammation7.4 M1 and M2 macrophages in adipose tissue7.5 ER stress response Section C: Links to diseases 8. Obesity8.1 Definition of obesity8.2 Adipogenesis8.3 Energy homeostasis8.4 Hormonal regulation of food anticipation8.5 Adipose tissue as an endocrine organ8.6 Inflammation in adipose tissue8.7 Genetics of obesity 9. Glucose homeostasis, insulin resistance and β cell failure9.1 Glucose homeostasis in health9.2 Principles of insulin signaling9.3 Central role of FOXO transcription factors9.4 Insulin resistance in skeletal muscle and liver9.5 β cell failure 10. Diabetes10.1 Definition of diabetes10.2 Failure of glucose homeostasis in T2D and its treatment10.3 Genetics of T2D10.4 Thrifty gene hypothesis 11. Hypertension, atherosclerosis and dyslipidemias11.1 Hypertension11.2 Mechanisms of atherosclerosis11.3 Cholesterol metabolism and lipoproteins11.4 Dyslipidemias 12. Metabolic syndrome12.1 Definitions of the metabolic syndrome12.2 Whole body's perspective on the metabolic syndrome12.3 Metabolic syndrome in key metabolic organs12.4. Genetic and epigenetic basis of the metabolic syndrome.
• Publisher Details: Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource (xxi, 222 pages), illustrations (some color)
• Subjects: 613.2; Medicine; Nutrition -- Genetic aspects; Nutrition -- Genetic aspects; Medical -- Nutrition; Dietetics & nutrition; Personal health and hygiene; Science -- Life Sciences -- Biology -- Molecular Biology; Medical research; Electronic books
• Languages: English
• ISBNs: 9783319304151; 3319304151; 3319304135; 9783319304137
• Related ISBNs: 9783319304137
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed June 21, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.