MicroRNA : cancer from molecular biology to clinical pactice /: cancer from molecular biology to clinical pactice. ([2015])

• Record Type: Book
• Further Information: Note: Gaetano Santulli, editor.
• Editors: Santulli, Gaetano
• Contents: Foreword; Contents; Contributors; Chapter 1: microRNAs in the Malignant Transformation Process; Introduction; Colorectal Cancer; Pancreatic Cancer; Malignant Peripheral Nerve Sheath Tumor; Prostate Cancer; Conclusion; References; Chapter 2: microRNA and Chronic Lymphocytic Leukemia; Chronic Lymphocytic Leukemia Before miRNAs Revolution; What Are miRNAs?; microRNA Signature in Chronic Lymphocytic Leukemia; miRNA's Mechanism of Action in CLL; miRNAs in CLL Mouse Models; miRNAs as Diagnostic and Prognostic Factors for CLL; miRNAs and RNA-Inhibition Therapy in CLL; Conclusions. MicroRNA Deregulation in GISTMicroRNAs Associated with Clinical and Pathological Features in GIST; MicroRNAs Associated with Chromosomal and Genetic Alterations in GIST; MicroRNAs in Imatinib Resistance in GIST; Clinical Implications of microRNAs in GIST; Conclusion; References; Chapter 5: Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy; Introduction; Pancreatic Cancer: A Major Clinical Problem; Deregulation of miRNAs in Pancreatic Cancer; Role of miRNAs in Pancreatic Cancer. MiRNAs in Pancreatic Cancer Initiation and Promotion miRNAs in Pancreatic Cancer Metastasis; miRNAs in Chemoresistance of Pancreatic Cancer; Opportunities for the Clinical Use of miRNAs in Pancreatic Cancer Management; miRNAs as Diagnostic Markers; miRNAs in Prognostic Assessment; miRNAs as Therapeutic Targets; Conclusion and Future Perspectives; References; Chapter 6: microRNAs and Colorectal Cancer; Introduction; MiRNAs and Their Relationship to the Hallmarks of Cancer; Regulation of Cell Proliferation and Evasion of Growth Suppressors; Evasion of Apoptosis. Regulating Immortalization or Senescence Induction of Angiogenesis; Migration Invasion and Metastasis; Promotion of Genomic Instability; Reprogramming of Energy Metabolism; Evasion of Immune System and Inflammation; Clinical Implications of miRNAs in Colorectal Cancer; MiRNAs as Diagnostics; Circulating miRNAs; Mucosal Colon Wash Fluid; Feces; microRNAs as Therapeutics; References; Chapter 7: microRNAs and Prostate Cancer; Introduction; Role of miRNA in the Epigenetic Reprogramming of Prostate Cancer Metastasis; Epigenetic Silencing by EZH2 Regulate miRNA.
• Publisher Details: Cham New York : Springer International Publishing
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (xi, 235 pages)
• Subjects: 616.994; Medicine; Tumor markers; Non-coding RNA; Cancer -- Genetic aspects; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cancer -- Genetic aspects; Non-coding RNA; Tumor markers; Biomarkers, Tumor; MicroRNAs; Neoplasms -- genetics; Science -- Life Sciences -- Cytology; Medical -- Oncology; Science -- Life Sciences -- Biochemistry; Medical -- Physiology; Cellular biology (cytology); Oncology; Zoology & animal sciences; Physiology; Cell physiology; Oncology; Biochemistry; Human physiology; Science -- Life Sciences -- Biology -- Molecular Biology; Medical research; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319237305; 3319237306; 3319237292; 9783319237299
• Related ISBNs: 9783319237299
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed December 17, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.