Nuclear receptors : from structure to the clinic /: from structure to the clinic. (2015)

• Record Type: Book
• Further Information: Note: Iain J. McEwan, Raj Kumar, editors.
• Editors: McEwan, I. J; Kumar, Raj
• Contents: 1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic -- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS.-2. Corticosteroid Receptors -- 3. Glucocorticoid Receptor Structure and Function -- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? -- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors -- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor -- 7. Structural Analysis of Heterodimeric Nuclear Receptors -- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS -- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) -- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes -- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC -- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors -- 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs).
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 572/.696; Medicine; Nuclear receptors (Biochemistry); Human genome; SCIENCE -- Life Sciences -- Biochemistry; Human genome; Nuclear receptors (Biochemistry); Receptors, Cytoplasmic and Nuclear; Biomedicine; Human Genetics; Endocrinology; Human Physiology; Medical -- Endocrinology & Metabolism; Medical -- Physiology; Endocrinology; Physiology; Human genetics; Endocrinology; Human physiology; Medical -- Genetics; Medical genetics; Electronic books
• Languages: English
• ISBNs: 9783319187297; 3319187295; 3319187287; 9783319187280
• Related ISBNs: 9783319187280
• Notes: Note: Includes bibliographical references and index.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.