Resistance to aromatase inhibitors in breast cancer. ([2015])

• Record Type: Book
• Further Information: Note: Alexey Larionov, editor.
• Editors: Larionov, Alexey (Alexey A.)
• Contents: Preface; Acknowledgments; Contents; 1 Clinical Use of Aromatase Inhibitors in Breast Cancer: History and Present ; Abstract ; Abbreviations; Introduction; From Beatson to Aromatase Inhibitors; Current Situation; Neo-Adjuvant Setting; Adjuvant Setting; Advanced Disease; Resistance to Aromatase Inhibition; Conclusion; References; 2 Structure, Regulation and Polymorphisms of the Aromatase Gene ; Abstract ; Abbreviations; Introduction: Tissue-Specific Expression of Human Aromatase; Structure of the Human Aromatase Gene; Expression of Aromatase in Breast Cancer Stroma. Transcriptional Regulation of the Aromatase Gene in Breast Cancer TissuesEpigenetic Regulation of Aromatase; Genetic Polymorphisms of the Human Aromatase Gene Associated with AI Response and Susceptibility to Breast Cancer; Post-transcriptional Regulation of Aromatase; Other Possible Factors that Affect Aromatase; Conclusion; References; 3 Structure, Function and Inhibition of Aromatase ; Abstract ; Abbreviations; Introduction; Crystal Structure of Human Placental Aromatase; Architecture of the Active Site; Structural Perspective on the Mechanism of Action; Membrane Integration. Oligomerization of AromataseRoles of Critical Residues; Motion and Flexibility of the Aromatase Molecule; Aromatase Inhibitors: Recent Developments; Phosphorylation of Aromatase and Estrogen Signaling: The New Frontier; Concluding Remarks; References; 4 In Vivo Models of AI Resistance ; Abstract ; Abbreviations; Introduction; Carcinogen Induced Syngeneic Tumor Model; Xenograft Model Using the Nude Mouse; Intra-tumoral Aromatase Xenograft Model; Aromatase Inhibitors as First Line Agents; AI Resistance Models; Estrogen Deprivation Based Models; LTED Model; UMB-1Ca Model. Letrozole Resistance ModelTransplanted Tumors; Activation of Growth Factor Pathways; Other Models; Variations Between the Models of AI Resistance; Discrepancies Between Animal Models and Clinical Data; Conclusion; References; 5 Ineffective Inhibition of Aromatase: A Cause for AI Resistance? ; Abstract ; Abbreviations; Introduction; The Aromatase Enzyme and Estrogen Disposition in Postmenopausal Women; Plasma Estrogen Measurements in Relation to Treatment with Aromatase Inhibitors; Tracer Studies; Tissue Estrogen Levels; Conclusions; References. 6 Understanding the New Biology of Estrogen-Induced Apoptosis and Its Application in Patient Care Abstract ; Abbreviations; Introduction; Selective Estrogen Receptor Modulators (SERMs); Contribution of SERM Resistance in Understanding Estrogen-Induced Apoptosis; Long-Term Estrogen Deprivation; Molecular Mechanisms of Estrogen-Induced Apoptosis; Estrogen-Induced Apoptosis: Clinical Translation Opportunities; Perspectives and Conclusions; References; 7 Ligand-Independent Signalling Through Estrogen Receptor Pathways in Breast Cancer ; Abstract ; Abbreviations; Introduction.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 616.99/4061; Medicine; Aromatase -- Antagonists -- Therapeutic use; Drug resistance in cancer cells; Breast -- Cancer -- Chemotherapy; HEALTH & FITNESS -- Diseases -- Cancer; MEDICAL -- Oncology; MEDICAL -- Chemotherapy; Breast -- Cancer -- Chemotherapy; Drug resistance in cancer cells; Breast Neoplasms -- drug therapy; Biomedicine; Cancer Research; Drug Resistance; Molecular Medicine; Medical -- Pharmacology; Science -- Life Sciences -- Biology -- Molecular Biology; Pharmacology; Medical research; Oncology; Drug interactions; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319179728; 3319179721; 3319179713; 9783319179711
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (Ebsco, viewed May 1, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.