Biomolecular interfaces : interactions, functions and drug design /: interactions, functions and drug design. (2015)

• Record Type: Book
• Further Information: Note: Ariel Fernández Stigliano.
• Authors: Fernández Stigliano, Ariel
• Contents: The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Extent: 1 online resource (xix, 372 pages), illustrations (some color)
• Subjects: 572/.33; Life sciences; Biomolecules; Biological interfaces; Biological interfaces; Biomolecules; Chemistry; Physical Sciences & Mathematics; Biochemistry; Molecular Biology; Life Sciences; Protein-Ligand Interactions; Membrane Biology; Molecular Medicine; Pharmaceutical Sciences/Technology; Biophysics and Biological Physics; Science -- Life Sciences -- Cytology; Science -- Life Sciences -- Biology -- Molecular Biology; Medical -- Pharmacy; Science -- Life Sciences -- Biophysics; Cellular biology (cytology); Medical research; Pharmaceutical technology; Biophysics; Cell membranes; Medicine; Pharmaceutical technology; Science -- Life Sciences -- Biochemistry; Proteins; Electronic books
• Languages: English
• ISBNs: 9783319168500; 3319168509
• Related ISBNs: 9783319168494; 3319168495; 9783319168494
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed May 1, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.