A tissue regeneration approach to bone and cartilage repair. ([2015])

• Record Type: Book
• Further Information: Note: Hala Zreiqat, Colin R. Dunstan, Vicki Rosen, editors.
• Editors: Zreiqat, Hala; Dunstan, Colin R; Rosen, Vicki
• Contents: Osteocytes and Bone Regeneration Abstract ; 1 Introduction; 2 Bone Matrix Repair by Osteocytes; 2.1 Osteocyte Apoptosis and Bone Matrix Microdamage; 2.2 Mechanisms of Osteocyte Mediated Matrix Repair; 2.2.1 RANKL Mediated Osteoclastogenesis; 2.2.2 Osteocyte Induction of Angiogenesis; 2.2.3 Osteocytic℗ Osteolysis; 2.2.4 Osteocyte Control of Bone Matrix Mineralisation; 3 Osteocytes in Fracture; 4 Osteocytes as Regulators of Bone Formation; 5 Summary; References; Skeletal Stem Cells for Bone and Cartilage Tissue Regeneration ; Abstract ; 1 Bone Marrow Microenvironment and Bone Marrow Stem Cells. 2 MSCs: Road to Clinical Use2.1 MSC Homing to Injured Tissues; 3 Specific Uses of BMSCs in Skeletal Regeneration; 3.1 Fractures and Bone Defects; 3.2 Osteoporosis; 3.3 Cartilage Repair and Rheumatic Diseases; 4 Concluding Remarks; References; Manipulation of Macrophages to Enhance Bone Repair and Regeneration ; Abstract ; 1 Introduction; 2 Role of Inflammation in Bone Healing; 3 Impact of Chronic Inflammation on Bone Healing; 4 Macrophage Polarization as a Potential Therapeutic Strategy; 5 Strategies to Actively Manipulate Macrophage Behavior; 5.1 Cell Delivery; 5.2 Drug and Protein Delivery. 5.3 Physical Modification of Scaffold Properties5.4 Selectively Delivery to Macrophages Using Nanoparticles; 6 Conclusions; References; Cartilage Regeneration Using Induced Pluripotent Stem Cell Technologies ; Abstract ; 1 The Structure and Limited Repair Capacity of Cartilage; 2 Cell Transplantation into Articular Cartilage Defects; 3 The Use of iPSC-Derived Chondrocytes; 3.1 Generation of iPSCs; 3.2 Improvement of the Safety of iPSCs; 3.3 Transplantation of iPSC-Derived Chondrocytes into Articular Cartilage Defects of Patients; 3.4 Development of an iPSC Library.
• Publisher Details: Cham Heidelberg New York Dordrecht London : Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource, illustrations
• Subjects: 617.4710592; Engineering; Bone regeneration; Tissue engineering; Biomedical materials; Biomedical engineering; Biomaterials; Microbiology; MEDICAL -- Surgery -- General; Biomedical materials; Bone regeneration; Tissue engineering; Technology & Engineering -- Material Science; Medical -- Microbiology; Science -- Life Sciences -- Biophysics; Materials science; Medical microbiology & virology; Biophysics; Technology & Engineering -- Engineering (General); Biomedical engineering; Bone Regeneration; Electronic books
• Languages: English
• ISBNs: 9783319132662; 3319132660
• Related ISBNs: 9783319132655
• Notes: Note: Includes bibliographical references.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.