Multi-targeted approach to treatment of cancer. ([2015])
- Record Type:
- Book
- Title:
- Multi-targeted approach to treatment of cancer. ([2015])
- Main Title:
- Multi-targeted approach to treatment of cancer
- Further Information:
- Note: Varsha Gandhi, Kapil Mehta, Rajesh Mehta, Sen Pathak, Bharat B. Aggarwal, editors.
- Editors:
- Gandhi, Varsha
Mehta, Kapil
Grover, R (Rajesh)
Pathak, Sen
Aggarwal, Bharat B - Contents:
- Contributors; Part I: Genetics/Genome/Microenvironment; Chapter 1: Diversity of Chromosomal Characteristics Among Mammals: With Special Reference to Laboratory Mouse in Cancer Resear ... ; 1.1 Introduction; 1.2 Do Large Size Mammals Have Longer and High Number of Chromosomes?; 1.3 Do X and Y Chromosomes Exist Intact in All Mammals?; 1.4 Distribution of Constitutive Heterochromatin in Mammalian Species; 1.5 Locations of Ribosomal Cistrons in Mammalian Chromosomes; 1.6 Distribution of Telomeric DNA in Mammalian Species. 1.7 Laboratory Mouse: Is the Animal Model or Muddle in Cancer Research1.8 Human Cloning and Producing Mini-Organs in Culture; References; Chapter 2: Genome-Based Multi-targeting of Cancer: Hype or Hope?; 2.1 Introduction; 2.2 Cancer Is an Age-Old Disease; 2.3 Cancer Is a Disease of Old Age; 2.4 Cancer Is More Common in Western/Developed Countries; 2.5 Cancer Is a Multigenic Disease; 2.6 Target-Specific Anticancer Drugs; 2.7 Anticancer Potential of Targeted Drugs; 2.8 Benefits of Most Targeted Drugs Is Marginal; 2.9 Most Targeted Drugs Are Highly Expensive. 2.10 Adverse Effects Associated with Targeted Therapies2.11 Multi-targeted Drugs Derived from Mother Nature Are Needed; Conclusions; References; Chapter 3: Chronic Lymphocytic Leukemia at the Genomic Level; 3.1 Rai and Binet Staging; 3.2 IgVH Gene Mutation and ZAP-70 Status; 3.2.1 IgVH Mutation Status; 3.2.2 ZAP-70 Status; 3.3 Cytogenetic Abnormalities; 3.3.1 13q14 Deletion; 3.3.2 17p Deletion; 3.3.3 11qContributors; Part I: Genetics/Genome/Microenvironment; Chapter 1: Diversity of Chromosomal Characteristics Among Mammals: With Special Reference to Laboratory Mouse in Cancer Resear ... ; 1.1 Introduction; 1.2 Do Large Size Mammals Have Longer and High Number of Chromosomes?; 1.3 Do X and Y Chromosomes Exist Intact in All Mammals?; 1.4 Distribution of Constitutive Heterochromatin in Mammalian Species; 1.5 Locations of Ribosomal Cistrons in Mammalian Chromosomes; 1.6 Distribution of Telomeric DNA in Mammalian Species. 1.7 Laboratory Mouse: Is the Animal Model or Muddle in Cancer Research1.8 Human Cloning and Producing Mini-Organs in Culture; References; Chapter 2: Genome-Based Multi-targeting of Cancer: Hype or Hope?; 2.1 Introduction; 2.2 Cancer Is an Age-Old Disease; 2.3 Cancer Is a Disease of Old Age; 2.4 Cancer Is More Common in Western/Developed Countries; 2.5 Cancer Is a Multigenic Disease; 2.6 Target-Specific Anticancer Drugs; 2.7 Anticancer Potential of Targeted Drugs; 2.8 Benefits of Most Targeted Drugs Is Marginal; 2.9 Most Targeted Drugs Are Highly Expensive. 2.10 Adverse Effects Associated with Targeted Therapies2.11 Multi-targeted Drugs Derived from Mother Nature Are Needed; Conclusions; References; Chapter 3: Chronic Lymphocytic Leukemia at the Genomic Level; 3.1 Rai and Binet Staging; 3.2 IgVH Gene Mutation and ZAP-70 Status; 3.2.1 IgVH Mutation Status; 3.2.2 ZAP-70 Status; 3.3 Cytogenetic Abnormalities; 3.3.1 13q14 Deletion; 3.3.2 17p Deletion; 3.3.3 11q Deletion; 3.3.4 Trisomy 12; 3.4 Genomics of CLL; 3.4.1 WGS and WES; 3.4.1.1 NOTCH1; 3.4.1.2 SF3B1; 3.4.1.3 BIRC3; 3.4.1.4 XPO1; 3.4.1.5 MYD88; 3.4.1.6 Clonal Evolution in CLL. 3.5 Transcriptome ProfilingReferences; Chapter 4: Apoptosis Pathways in Chronic Lymphocytic Leukemia: Role of the Microenvironment and Therapeutic Strategies; 4.1 Introduction; 4.2 Intrinsic and Extrinsic Factors Contribute to Biology of CLL Cells; 4.2.1 Intrinsic Factors: Genetic Aberrations in CLL; 4.2.2 Intrinsic Factors: Apoptotic Imbalance in CLL Cells; 4.2.3 Extrinsic Factors: Contribution of the Microenvironment to CLL Cell Survival; 4.3 Role of Apoptosis Pathway Members in CLL Pathophysiology; 4.3.1 B-cell Receptor, TNF Receptor Super Family, DED, and CARD Family. 4.3.2 NF-kappaB, Caspase, and IAP Families4.3.3 Bcl-2 Family Antiapoptotic and Proapoptotic Proteins; 4.4 Microenvironment-Dependent Regulation of Apoptotic Pathway Proteins; 4.5 Therapeutic Strategies to Counter Survival Signals in CLL; 4.5.1 CLL Therapy: Standard of Care; 4.5.2 CLL Therapy: Targeting BCR Pathway; 4.5.3 CLL Therapy: Targeting Bcl-2 and IAPs; Conclusions; References; Chapter 5: Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside; 5.1 Introduction; 5.2 TAM Origin and Accumulation. … (more)
- Publisher Details:
- Cham : Adis
- Publication Date:
- 2015
- Copyright Date:
- 2015
- Extent:
- 1 online resource, illustrations (some color)
- Subjects:
- 616.99406
Medicine
Cancer -- Treatment
HEALTH & FITNESS -- Diseases -- General
MEDICAL -- Clinical Medicine
MEDICAL -- Diseases
MEDICAL -- Evidence-Based Medicine
MEDICAL -- Internal Medicine
Cancer -- Treatment
Neoplasms -- therapy
Medical -- Pharmacy
Medical -- Oncology
Pharmaceutical technology
Oncology
Oncology
Pharmaceutical technology
Oncology
Electronic books - Languages:
- English
- ISBNs:
- 9783319122533
3319122533 - Related ISBNs:
- 9783319122526
3319122525
9783319122526 - Notes:
- Note: Includes bibliographical references.
Note: Online resource; title from PDF title page (EBSCO, viewed February 4, 2015). - Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.361176
- Ingest File:
- 01_327.xml