Kinase drug discovery. (2018)

• Record Type: Book
• Further Information: Note: Edited by Richard A. Ward, Frederick W. Goldberg.
• Editors: Ward, Richard A; Goldberg, Frederick
• Contents: Introduction to Kinase Drug Discovery - Modern Approaches; New Screening Approaches for Kinases; The Screening and Design of Allosteric Kinase Inhibitors; Covalent Inhibition of Kinases; Small Molecule Macrocyclic Kinase Inhibitors; The Design of Brain Penetrant Kinase Inhibitors; Cutting Edge Approaches to Structure-based Computational Modelling of Kinases; The Properties of Kinase Inhibitors; Assessment and Optimisation of Kinases Inhibitor Selectivity to Achieve Candidates with an Appropriate Safety Profile; Drugging the Kinome; The Importance of Kinase Mutations in Cancer Drug Discovery; Kinase Inhibition for Immuno-oncology; A Structural Perspective of the Pseudokinome: Defining the Targetable Space; The Future of Kinase Therapeutics; Subject Index
• Publisher Details: Place of publication not identified : Royal Society of Chemistry
• Publication Date: 2018
• Extent: 1 online resource (413 pages)
• Subjects: 615.35; SCIENCE / Chemistry / Clinical; SCIENCE / Life Sciences / Molecular Biology; Enzymology; Molecular biology; Protein kinases -- Inhibitors
• Languages: English
• ISBNs: 9781788015639; 1788015630
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.