Biomarkers for Alzheimer's disease drug development. (2018)

• Record Type: Book
• Further Information: Note: Edited by Robert Perneczky.
• Editors: Perneczky, Robert
• Contents: Epidemiology of Dementia: The Burden on Society, the Challenges for Research -- Population-based Approaches to Alzheimers Disease Prevention -- Systems Biology Methods for Alzheimers Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials -- CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform -- CSF N-glycomics using MALDI MS Techniques in Alzheimers Disease -- MicroRNA Profiling of Alzheimers Disease Cerebrospinal Fluid -- Validation of a Chemiluminescence Immunoassay for Measuring Amyloid- in Human Blood Plasma -- Mass Spectrometry-based Metabolomic Multiplatform for Alzheimers Disease Research -- Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases -- Functional Magnetic Resonance Imaging in Alzheimer Disease Drug Development -- Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies -- Hybrid PET-MRI in Alzheimers Disease Research -- Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers -- The use of 18F-FDG PET in the Diagnostic Workup of Alzheimers Dementia -- Quantification of Tau Load in Alzheimers Disease Clinical Trials Using Positron Emission Tomography -- Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach -- Unbiased Lipidomics and Metabolomics of Human Brain Samples -- Neuropathological Assessment as an Endpoint in Clinical Trial Design -- Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimers Disease Biomarker Discovery -- Telomere length shortening in Alzheimers disease procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study -- Quantifying miRNA Deregulation in Alzheimers Disease -- Imaging of Microglial Activation in Alzheimers Disease by [11C]PBR28 PET -- In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models -- Cognitive Assessment in Alzheimers Disease Clinical Trials -- Data Mining and Machine Learning Methods for Dementia Research.
• Publisher Details: New York : Humana Press
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource (372 pages)
• Subjects: 616.8/311; Alzheimer's disease; Biochemical markers; Alzheimer Disease -- drug therapy; Biomarkers; Drug Discovery; Alzheimer's disease; Biochemical markers; Laboratory Manual
• Languages: English
• ISBNs: 9781493977048
• Related ISBNs: 9781493977031
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.