Stem cell-derived models in toxicology. (2016)

• Record Type: Book
• Further Information: Note: Edited by Mike Clements, Axion BioSystems, Inc., Atlanta, GA, USA, Liz Roquemore, Cell Applications, GE Healthcare, Cardiff, UK.
• Editors: Clements, Mike; Roquemore, Liz
• Contents: 1. Stem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the 'Proclinical Space' Gary Gintant and Stefan Braam 2. Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk Sei Kameoka and Eric Chiao 3. Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology Muthukrishnan Renganathan, Haiyang Wei, and Yong Zhao 4. Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes Alison Obergrussberger, Claudia Haarmann, Sonja Stölzle-Feix, Nadine Becker, Atsushi Ohtsuki, Andrea Brüggemann, Michael George, and Niels Fertig 5. The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential Daniel C. Millard, Mike Clements, and James D. Ross 6. Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions Graham T. Dempsey and Christopher A. Werley 7. HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems Ralf Kettenhofen 8. Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes Emily R. Pfeiffer, Ross Whittaker, Raquel Vega, Fabio Cerignoli, Patrick M. McDonough, and Jeffrey H. Price 9. Decoding Ca2+ Signals as a Non-Electrophysiological Method for Assessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes Christopher H. George and David H. Edwards 10. Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes Alison Obergrussberger, Ulrich Thomas, Sonja Stölzle-Feix, Nadine Becker, Krisztina Juhasz; Leo Doerr, Matthias Beckler, Michael George, and Niels Fertig 11. Edge Detection for Contractility Measurements with Cardiac Spheroids Christian Zuppinger 12. Contractile Force Readout of hESC-Cardiomyocytes Carlota Oleaga, Gregg Legters, L. Richard Bridges, Lee Kumanchik, Candace Martin, Yunqing Cai, Mark Schnepper, Christopher W. McAleer, Christopher J. Long, and James J. Hickman 13. In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models Liz Roquemore, Ariel Kauss, Catherine Hather, Nick Thomas, and Hirdesh Uppal 14. Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes Janos Kriston-Vizi, Sian E. Harding, and Gábor Földes 15. Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA) Udo Kraushaar, Elke Guenther, and Dietmar Hess 16. Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies Brenton R. Ware and Salman R. Khetani.
• Publisher Details: New York : Humana Press
• Publication Date: 2016
• Copyright Date: 2017
• Extent: 1 online resource (341 pages)
• Subjects: 615.19; Medicine; Drug Evaluation, Preclinical; Stem Cells -- drug effects; Toxicity Tests; Drug-Related Side Effects and Adverse Reactions -- prevention & control; Drug development; Toxicology; Medical -- Pharmacology; Pharmacology
• Languages: English
• ISBNs: 9781493966615
• Related ISBNs: 9781493966592
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.