Endothelial signaling in development and disease. ([2015])

• Record Type: Book
• Further Information: Note: Mirko HH Schmidt, Stefan Liebner.
• Editors: Schmidt, Mirko HH; Liebner, Stefan
• Contents: Foreword; Contents; About the Editors; Contributors; Part I; Development and Differentiation of the Vascular System; Chapter-1; VEGF and Notch Signaling in angiogenesis ; 1.1 Overview of Vascular Morphogenesis; 1.1.1 Sprouting; 1.1.2 Intussusceptive Angiogenesis; 1.1.3 Shear Stress; 1.1.4 EPCs; 1.1.5 Embryoid Bodies; 1.2 Signaling Pathways Governing Blood Vessel Formation; 1.2.1 Molecular Structure of VEGFs and VEGFRs; 1.2.2 Signaling for Angiogenesis: VEGF and VEGFR2; 1.2.3 Angiogenic Modifiers: VEGFR1, VEGF-B and PIGF; 1.2.4 Fibroblast Growth Factor (FGF); 1.2.5 Ang/Tie Signaling. 1.2.6 Hypoxia-inducible Factor (HIF)1.2.7 NO Signaling; 1.2.8 The Notch Signaling Pathway; 1.3 Blood-vessel Formation at the Molecular and Cellular Level; 1.3.1 Notch in Angiogenesis; 1.3.2 Negative Regulators of Notch Signaling in ECs; 1.3.3 Notch and Cellular Signaling in ECs; 1.3.4 Arterial Specification: Notch Meets Wnt; 1.4 VEGF and Notch: the Interplay; 1.4.1 The Physiological Interplay: EC Sprouting; 1.4.2 Pathological Interplay: Tumor Angiogenesis; 1.4.3 Targeting Tumor Angiogenesis; 1.5 Concluding Remarks; References; Chapter-2. 2.1 Zebrafish Vasculogenesis and Arteriovenous Specification 2.2 Molecular Cues During Vasculogenesis ; 2.3 Molecular Regulation of Arterial-Venous Specification ; 2.3.1 EphrinB2/Eph Receptor B4 ; 2.3.2 Vascular Endothelial Growth Factor and Sonic Hedgehog ; 2.3.3 Notch and Hey2 ; 2.3.4 SoxF Family Members ; 2.3.5 Fox and ETS ; 2.4 Summary ; References; Chapter-3; Pericytes in Vascular Development and Function; 3.1 Introduction; 3.2 Cell Biology of Pericytes; 3.2.1 Cell Morphology; 3.2.2 Heterogeneity of Pericytes; 3.2.3 Cell Adhesion to Endothelial Cells. Fibroblast Growth Factor Signaling in Vascular Development4.1 Overview of the Fibroblast Growth Factor (FGF) Family; 4.2 The Family of FGF Receptors (FGFRs); 4.3 Alternative Splicing Yields Structurally and Functionally Diverse FGFRs; 4.4 Three Major Pathways are Involved in Canonical FGF/FGFR Signal Transduction; 4.5 Negative Regulation of FGFR1 Signaling; 4.6 FGF Co-Receptors and Extracellular Matrix Components Contribute to FGF-Dependent Signal Transduction; 4.7 Current Knowledge About FGFs and Their Receptors in Vascular Development is Limited.
• Publisher Details: New York : Springer
• Publication Date: 2015
• Extent: 1 online resource (xiv, 401 pages)
• Subjects: 571.7/4; Medicine; Cellular signal transduction; Endothelial cells; SCIENCE / Life Sciences / Anatomy & Physiology; Cellular signal transduction; Endothelial cells; Physiology; Human Anatomy & Physiology; Health & Biological Sciences; Signal Transduction; Biomedicine; Human Physiology; Cell Physiology; Hematology; Angiology; Systems Biology; Science -- Life Sciences -- Cytology; Medical -- Hematology; Medical -- Internal Medicine; Science -- Life Sciences -- General; Cellular biology (cytology); Haematology; Cardiovascular medicine; Life sciences: general issues; Human physiology; Cell physiology; Hematology; Angiography; Biological models; Medical -- Physiology; Physiology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9781493929078; 1493929070
• Related ISBNs: 9781493929061; 1493929062; 9781493929061
• Notes: Note: Includes bibliographical references and index.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.