Cell signaling during mammalian early embryo development. ([2015])

• Record Type: Book
• Further Information: Note: Henry J. Leese, Daniel R. Brison, editors.
• Editors: Leese, Henry J; Brison, Daniel R
• Contents: Preface; Contents; Contributors; Chapter-1; Cell Signalling During Blastocyst Morphogenesis; 1.1 Introduction; 1.2 Intrinsic Signals Regulating Blastocyst Morphogenesis; 1.2.1 Cell Signalling at Fertilisation and Activation of the Development Programme; 1.2.2 Cell Signalling at Compaction; 1.2.3 Cell Signalling and Blastocyst Formation; 1.2.4 Cell Signalling and the Stabilisation of Emergent Cell Lineages; 1.3 Extrinsic Signalling Pathways; 1.3.1 Insulin and Amino Acid Signalling-The mTORC Signalling Network; 1.3.2 Energy Homeostasis-The AMPK Signalling Network. 1.3.3 Lipid Metabolism and Fatty Acid Signalling1.3.4 The Role of Methyl Group Availability; 1.4 Conclusions; References; Chapter-2; Amino Acids and Conceptus Development During the Peri-Implantation Period of Pregnancy; 2.1 Introduction; 2.2 Leucine, Arginine and Glutamine; 2.3 MechanisticTarget of Rapamycin (MTOR); 2.4 Nitric Oxide and Trophoblast Motility; 2.5 Polyamines and Trophoblast Motility; 2.6 Amino Acids in Uterine Flushings of Ewes and Gilts during the Peri-Implantation Period of Pregnancy; 2.7 Nutrient Transporters in Uterine Epithelia and Conceptus Trophectoderm (see Table 2.5). 2.8 Expression of Components of the MTOR Cell Signaling Pathway in Ovine Conceptus Trophectoderm2.9 Amino Acids Stimulate MTOR Cell Signaling; 2.10 Beneficial Effects of Dietary Arginine Supplementation on Embryonic/Fetal Survival and Growth in Mammals; 2.11 Summary; References; Chapter-3; The Role of Hexosamine Biosynthesis and Signaling in Early Development; 3.1 The Embryo and its Environment; 3.2 A Role for Glucose in Early Development?; 3.3 Glucose Primes Embryos to Adapt to Their Environment; 3.4 Hexosamine Biosynthesis: An Embryonic Nutrient-Sensing Pathway. 3.5 The Response Path: N-Linked Vs. O-Linked Glycosylation?3.6 Hexosamine Signalling: A Nutrient Response Pathway; 3.6.1 The Enzymes; 3.6.2 The Targets; 3.7 O-GlcNAcylation in Development; 3.8 The HSP: Sensor of an Adverse Environment?; 3.9 Perturbed O-GlcNAcylation and Embryo Development; 3.9.1 Embryotoxic Effects of Hyperglycemia and O-GlcNAcylation; 3.9.2 Glucosamine as a Hyperglycemic Mimetic; 3.9.3 Periconceptional HSP Pertubation and Postnatal Outcomes; 3.10 Nutrient Stress, Embryonic Programming and O-Linked Glycosylation; 3.11 What Makes the Early Embryo More Susceptible? 3.12 ConclusionReferences; Chapter-4; Molecular Biology of the Stress Response in the Early Embryo and its Stem Cells; 4.1 Introduction; 4.2 Early events in Embryogenesis Balancing Anabolism and Stress During Early Embryonic Programming; 4.2.1 Defining Stress and Categorizing Classes of Stress by the Transcription Factors in the Survival Responses of Somatic Cells, Stem Cells and Embryos; 4.2.2 Integrating Maternal Nutritional/energy Status to Enable Peri-Implantation Embryogenesis to use Energy for Normal or Stressed Development; 4.2.3 Stress During IVF/ART.
• Publisher Details: New York [New York] : Springer
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 573.619; Life sciences; Mammals -- Reproduction; Embryos; Cells; SOCIAL SCIENCE -- Anthropology -- Physical; Cells; Embryos; Mammals -- Reproduction; Life Sciences; Embryology; Cell Biology; Reproductive Medicine; Science -- Life Sciences -- Biology -- Molecular Biology; Health & Fitness -- Diseases -- Genetic; Cellular biology (cytology); Reproductive medicine; Embryology; Cytology; Reproductive Medicine; Science -- Life Sciences -- Biology -- Developmental Biology; Electronic books
• Languages: English
• ISBNs: 9781493924806; 1493924796; 9781493924790
• Related ISBNs: 149392480X; 9781493924790
• Notes: Note: Includes bibliographical references and index.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.