Biophysical regulation of vascular differentiation and assembly. (2018)

• Record Type: Book
• Further Information: Note: Sharon Gerecht editor.
• Other Names: Gerecht, Sharon
• Contents: Intro; Dedication; Preface; Contents; Chapter 1: Molecular Control of Capillary Tube Morphogenesis and Maturation Through Endothelial Cell-Pericyte Interactions: Regulation by Small GTPase-Mediated Signaling, Kinase Cascades, Extracellular Matrix Remodeling, and Defined Growth Factors; 1.1 Introduction; 1.2 Concepts in Vascular Tube Morphogenesis in 3D Extracellular Matrices; 1.2.1 Extracellular Matrix and Vascular Morphogenesis; 1.2.2 Differential Effects of ECM Components on Vascular Tube Morphogenesis; 1.3 Review of Work 1.3.6 Key Role for Polarized Subapical Microtubule Modifications to Direct the Trafficking and Fusion of Pinocytic Vacuoles to Regulate Apical Membrane Development During EC Lumen Formation1.3.7 Critical Functional Role for MT1-MMP in EC Lumen and Tube Formation in 3D Collagen Matrices; 1.3.8 MT1-MMP-Dependent EC Lumen and Tube Formation Leads to the Formation of a Network of Physical Spaces Within the ECM Termed Vascular Guidance Tunnels 1.3.9 Cdc42 and MT1-MMP Are Functionally Interdependent Signaling Molecules Which Are Components of an EC Lumen Signaling Complex that Controls EC Tubulogenesis in 3D Extracellular Matrices1.3.10 Critical Role for MMPs in the Molecular Control of Vascular Tube Regression Responses in 3D Collagen Matrices; 1.3.11 Critical Functional Role for EC-Generated Vascular Guidance Tunnels During Blood Vessel Assembly in 3D Matrices; 1.3.12 Pericyte Recruitment to Vascular Guidance Tunnels Induces Vascular Tube Stabilization 1.3.13 Molecular Mechanisms Underlying Why Pericytes Are Able to Stabilize EC-Lined Tube Networks1.3.14 Pericyte Recruitment to EC-Lined Tubes Stimulates ECM Remodeling Events and Vascular Basement Membrane Matrix Assembly; 1.3.15 Critical Functional Role for Fibronectin Matrix Assembly During Vascular Development; 1.3.16 Important Functional Role for Collagen Type IV in EC-Pericyte Tube Co-Assembly and Maturation Events; 1.3.17 Pericyte TIMP-3 Contributes to Vascular Basement Membrane Matrix Assembly by Increasing Collagen Type IV Deposition or Stability
• Edition: Second Edition
• Publisher Details: Cham, Switzerland : Springer Nature Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.02774; Physics; Stem cells; Blood-vessels -- Growth; Biophysics; Biomedical engineering; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Technology & Engineering -- Engineering (General); Science -- Life Sciences -- Cytology; Biomedical engineering; Genetics (non-medical); Science -- Life Sciences -- Biophysics; Biophysics; Electronic books
• Languages: English
• ISBNs: 9783319993195; 3319993194
• Related ISBNs: 9783319993188
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed November 13, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.