Molecular mechanisms of notch signaling. ([2018])

• Record Type: Book
• Further Information: Note: Tilman Borggrefe, Benedetto Daniele Giaimo, editors.
• Editors: Borggrefe, Tilman; Giaimo, Benedetto Daniele
• Contents: Introduction to molecular mechanisms in notch signal transduction and disease pathogenesis / Benedetto Daniele Giaimo, Tilman Borggrefe -- Molecular mechanisms of receptor/ligand interactions. Structural insights into notch receptor-ligand interactions / Penny A. Handford, Boguslawa Korona, Richard Suckling, Christina Redfield, Susan M. Lea -- The molecular mechanism of notch activation / Klaus N. Lovendahl, Stephen C. Blacklow, Wendy R. Gordon -- Regulation of notch function by O-glycosylation / Beth M. Harvey, Robert S. Haltiwanger -- Modeling the notch response / Udi Binshtok, David Sprinzak -- Endocytic trafficking of the notch receptor / Bj̲örn Schnute, Tobias Troost, Thomas Klein -- Intracellular signaling mechanisms. The notch interactome: complexity in signaling circuitry / Diana M. Ho, K. G. Guruharsha, Spyros Artavanis-Tsakonas -- Integration of drosophila and human genetics to understand notch signaling related diseases / Jose L. Salazar, Shinya Yamamoto -- Mechanisms of non-canonical signaling in health and disease: diversity to take therapy up a notch? / Victor Alfred, Thomas Vaccari -- The notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms / Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti -- Notch and neurogenesis / Anna Engler, Runrui Zhang, Verdon Taylor -- Notch and stem cells / Anna Bigas, Cristina Porcheri -- Oscillatory control of notch signaling in development / Ryoichiro Kageyama, Hiromi Shimojo, Akihiro Isomura -- CSL-associated corepressor and coactivator complexes / Franz Oswald, Rhett A. Kovall -- Disease links and therapeutics. Notch and senescence / Matthew Hoare, Masashi Narita -- Control of blood vessel formation by notch signaling / Fabian Tetzlaff, Andreas Fischer -- Notch and T cell function: a complex tale / Jyothi Vijayaraghavan, Barbara A. Osborne -- Notch in leukemia / Anna C. McCarter, Qing Wang, Mark Chiang.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource (xxvii, 398 pages), illustrations (chiefly color)
• Subjects: 571.7/4; Life sciences; Cellular signal transduction; Notch proteins; SCIENCE / Life Sciences / Anatomy & Physiology; Cellular signal transduction; Notch proteins; Receptors, Notch -- metabolism; Signal Transduction -- physiology; Science -- Life Sciences -- Biochemistry; Proteins; Cell receptors; Biochemistry; Electronic books
• Languages: English
• ISBNs: 9783319895123; 3319895125
• Related ISBNs: 9783319895116; 3319895117
• Notes: Note: Includes bibliographical references and index.; Note: Description based on online resource; title from electronic title page (SpringerLink, viewed July 24, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.