Mitochondrial biology and experimental therapeutics. ([2018])

• Record Type: Book
• Further Information: Note: Paulo J. Oliveira, editor.
• Editors: Oliveira, Paulo J
• Contents: Intro; Foreword; Contents; Part I: Mitochondrial Biology; Introduction: Mitochondria, the Cell Furnaces; References; Mitochondria: Where Are They Coming From?; 1 Introduction; 2 Problems and Controversies Regarding the Precise Bacterial Origin of Mitochondria; 3 Integrated Approaches to Identify Possible Relatives of Proto-mitochondria; 4 Conclusion; References; Mitochondrial Dynamics: A Journey from Mitochondrial Morphology to Mitochondrial Function and Quality; 1 Mitochondrial Fusion and Fission: Shaping the Mitochondrial Network; 1.1 Mitochondrial Fusion. 1.1.1 Mitochondrial Fusion Proteins1.1.2 Regulation of Mitochondrial Fusion; 1.2 Mitochondrial Fission; 1.2.1 Mitochondrial Fission Proteins; 1.2.2 Regulation of Mitochondrial Fission; 2 Mitochondrial Dynamics Regulates Mitochondrial Function and Quality; 2.1 Regulation of Mitochondrial Function by Mitochondrial Dynamics; 2.2 Regulation of Mitochondrial Quality by Mitochondrial Dynamics; References; Mitochondria and Ageing; 1 The Free Radical Theory of Ageing. The Mitochondrial Free Radical Theory of Ageing as Proposed by Miquel; 2 Mitochondrial Disruption of Cell Signalling in Ageing. 3 Mitochondrial DNA Is More Susceptible to Damage than Nuclear DNA4 Mitochondria Are Damaged Inside Cells; 5 Sex Differences in Free Radical Production and Its Relationship with Longevity; 6 Mitochondrial Diseases; 7 Toxicological Aspects: The Treatment of AIDS with Zidovudine Causes Mitochondrial Pathology that Explains Muscle Damage Associated with AIDS Treatment; 8 Alzheimer's Disease; References; The Mitochondrial Permeability Transition Pore; 1 Mitochondrial Permeability Transition; 2 Mitochondrial Permeability Transition Pore Complex: Molecular Structure; 2.1 Regulatory Components. 3 Pathological Relevance3.1 Ischemia/Reperfusion Injury; 3.2 Cancer; 3.3 Neurodegenerative Diseases; 4 Conclusions; References; Mitochondrial Regulation of Cell Death; 1 Introduction; 2 Mitochondrial Reactive Oxygen Species and Mitochondrial Dysfunction; 3 Mitochondrial Calcium as a Trigger of Cell Death; 4 BCL-2 Family Members; 5 Mitochondrial Intermembrane Space Proteins; 6 Mitophagy; 6.1 Molecular Mechanisms; 6.2 Mitophagy, Cell Death or Cytoprotection; 7 Conclusion and Perspectives; References; Mitochondria in Liver Diseases; 1 Introduction. 2 Mitochondria Contribute to the Progression of Liver Disease3 Mitochondria Changes in Liver Diseases; 3.1 Non-alcoholic Fatty Liver Disease (NAFLD); 3.2 Alcoholic Liver Disease (ALD); 3.3 Hepatitis C Virus (HCV) Infection; 3.4 Hemochromatosis; 3.5 Wilson's Disease; 3.6 Chronic Cholestatic Disorders; 4 Assessment of Liver Mitochondrial Function In Vivo; 4.1 Respiratory Chain Activity; 4.2 Alpha-Ketoacid Dehydrogenase; 4.3 Octanoic Acid; 4.4 Benzoic Acid; 4.5 Urea Production; 4.6 [31P] Nuclear Magnetic Resonance Spectroscopy; 5 Conclusions; References.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource
• Subjects: 571.6/57; Medicine; Mitochondrial pathology; SCIENCE -- Life Sciences -- Anatomy & Physiology; Mitochondrial pathology; Science -- Chemistry -- Clinical; Medical -- Biochemistry; Science -- Life Sciences -- Cytology; Biochemistry; Cellular biology (cytology); Toxicology; Biochemistry; Cytology; Medical -- Pharmacology; Pharmacology; Electronic books
• Languages: English
• ISBNs: 9783319733449; 3319733443
• Related ISBNs: 9783319733432; 3319733435
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed March 26, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.