Acute promyelocytic leukemia : a clinical guide /: a clinical guide. ([2018])

• Record Type: Book
• Further Information: Note: Oussama Abla, Francesco Lo Coco, Miguel A. Sanz, editors.
• Editors: Abla, Oussama; Lo Coco, Francesco; Sanz, Miguel A
• Contents: Intro; Preface; Contents; Contributors; 1: History of Acute Promyelocytic Leukemia; Introduction; A Distinct Entity: "A Special Type of Leukemia" (1957-1987); The Clinical Description; A Controversy About Treatment; A Cytogenetic Signature; A New Paradigm: The Differentiation of Malignant Cells; Abolishing the Dogma of the Irreversible Status of Malignant Cells; An Experimental Approach; A Clinical Approach; All-Trans-Retinoic Acid as a Potential Candidate for Differentiation Therapy of APL; The Dinner that Initiated All-Trans-­Retinoic Acid Treatment for APL (1985); Hoops and Hurdles No More ProductIs APL a Pseudo-Leukemia?; Early Relapses with ATRA; Hope for a Curable Disease; Worldwide Enthusiasm; New Clinical Horizons, Unknown Conditions; Nonstandard Regimens; Molecular Defects; First Attempts at Molecular Approaches; Clinical Consequences: Diagnostic and Follow-Up Tools; Toward a Biological Explanation of Oncogenesis and Restoration; Arsenic, a Manchurian Traditional Medicine (1995); A Second Era for Clinicians; A Better Biological Understanding; ATRA-ATO Combination in Patients: From Curable to Cured APL; And Beyond: Lessons and Questions; References 2: Molecular Targets of Treatment in Acute Promyelocytic LeukemiaIntroduction; The Translocation Partners: RARA and PML; The Oncoprotein PML/RARA; Therapeutic Effects of Retinoic Acid in APL; Uncoupling Differentiation and Loss of Clonogenicity Under RA Treatment; RA-Induced PML/RARA Degradation; Role of PML and p53 in the Cure of APL Under RA Treatment; Therapeutic Effects of Arsenic Trioxide in APL; ATO-Induced PML NB Reformation and PML/RARA Degradation; RA and ATO Synergy in APL Cure; References; 3: The Leukemic Stem Cell; The Cancer Stem Cell Theory; Defining Stemness in Leukemia The Effects of ATRA and ATO on the Coagulopathy of APLManagement of the Coagulopathy; Platelet Transfusions, Heparin, and Antifibrinolytic Agents; References; 6: Early Death in Acute Promyelocytic Leukemia; Introduction; Definition and Timing of Early Death; Early Death in the Pre-ATRA Era; Early Death in Clinical Trials vs. Population-Based Studies; Causes of Early Death; Bleeding; Infections; Thrombosis; Differentiation Syndrome (DS); Organ Failure; Early Death Risk Factors; Role of ATRA in Early Death; Early Death over Time; Prevention of ED; References
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.99/419; Medicine; Acute myeloid leukemia; Acute myeloid leukemia -- Treatment; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Medicine & Public Health; Hematology; Oncology; Acute myeloid leukemia; Medical -- Oncology; Oncology; Hematology; Oncology ; Medical -- Hematology; Haematology; Electronic books
• Languages: English
• ISBNs: 9783319642574; 3319642561; 9783319642567
• Related ISBNs: 331964257X; 9783319642567
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed May 02, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.