Mechanisms of molecular carcinogenesis. Volume 2 (2017)

• Record Type: Book
• Further Information: Note: Johannes Haybaeck, editor.
• Editors: Haybaeck, Johannes
• Contents: Preface; Contents; 1: Molecular Classification of Breast Cancer; 1.1 Introduction; 1.2 Histopathological Classification of In Situ and Invasive Breast Cancer; 1.2.1 Histological Features of Ductal Carcinoma In Situ; 1.2.2 Histological Types and Grade of Invasive Breast Cancers; 1.3 Molecular Classification of Invasive Breast Carcinoma; 1.3.1 Gene Expression Profiling in Breast Cancer; 1.3.2 Immunohistochemical Surrogates for Intrinsic Subtypes; 1.3.3 Genome Profiling in Breast Cancer; 1.3.4 Special Subtypes; 1.3.5 Familial Breast Cancer. 1.4 Molecular Classification of Ductal Carcinoma In Situ1.4.1 Molecular Subtypes in DCIS; 1.5 Future Perspectives; References; 2: Nonmelanoma Skin Cancer Actinic Keratosis and Squamous Cell Carcinoma; 2.1 Introduction; 2.2 Histological Classifications; 2.3 Influencing Factors for Carcinogenesis; 2.3.1 UV Radiation; 2.3.2 Inflammation and Cancer; 2.4 Immune Cells in Tumor Genesis; 2.4.1 Innate Immune Cells; 2.4.2 Adaptive Immune Cells; 2.4.3 Tumor Microenvironment; 2.5 Hypoxia or Oxidative Stress and Inflammation; 2.6 Viral Infection; 2.6.1 Acute and Chronic Viral Infection. 2.6.2 Treatment: Actinic Keratosis2.7 Targeted Therapies in AK; 2.7.1 5 Fluorouracil (5-FU); 2.7.2 Imiquimod; 2.7.3 Cyclooxygenase (COX)-2 Inhibitors; 2.7.4 Ingenol Mebutate; 2.7.5 Photodynamic Therapy (PDT); 2.7.6 Treatment: Cutaneous Squamous Cell Cancer; 2.8 Future (Targeted) Therapies or Treatment Options Used in Clinical Studies; 2.8.1 Anti-epidermal Growth Factor Receptors (EGFR); References; 3: Molecular Pathogenesis of Bone Tumours; 3.1 Introduction; 3.2 Tumour Types; 3.2.1 Cartilage Tumours; 3.2.2 Osteogenic Tumours; 3.2.3 Ewing Sarcoma; 3.2.4 Haematopoietic Tumours. 3.2.5 Giant Cell Tumours3.2.6 Notochordal Tumours (Chordoma); 3.2.7 Tumours of Undefined Neoplastic Nature; 3.2.7.1 Aneurysmal Bone Cysts; 3.2.7.2 Simple Bone Cyst; 3.2.7.3 Fibrous Dysplasia; 3.2.7.4 Osteofibrous Dysplasia; 3.2.7.5 Langerhans Cell Histiocytosis; 3.2.7.6 Erdheim-Chester Disease; 3.2.7.7 Chest Wall Hamartoma; 3.3 Molecular Pathogenesis; 3.3.1 AEG-1; 3.3.2 ATRX; 3.3.3 CDKN2A; 3.3.4 CTGF; 3.3.5 ET-1; 3.3.6 EXT1; 3.3.7 GNAS; 3.3.8 IDH1; 3.3.9 MDM2; 3.3.10 MEF2D; 3.3.11 MET; 3.3.12 NKD2; 3.3.13 PRIM1; 3.3.14 RUNX Family; 3.3.14.1 RUNX2; 3.3.14.2 RUNX3. 3.3.15 SATB23.3.16 TP53; 3.3.17 WIF-1; 3.4 Syndromes; 3.4.1 Li-Fraumeni Syndrome; 3.4.2 Mazabraud Syndrome; 3.4.3 McCune-Albright Syndrome; 3.4.4 Ollier Disease (Enchondromatosis); 3.4.5 Paget's Disease of Bone; 3.4.6 Retinoblastoma; 3.4.7 Rothmund-Thomson Syndrome; 3.4.8 Werner Syndrome; References; 4: Molecular and Cellular Mechanisms of Carcinogenesis in the Large Bowel; 4.1 Introduction; 4.2 Molecular Classification of Colorectal Cancer; 4.2.1 The Chromosomal Instability (CIN) Pathway; 4.2.2 Microsatellite Instability (MSI) Pathway and Lynch Syndrome (LS).
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource, color illustrations
• Subjects: 616.99/4071; Medicine; Carcinogenesis -- Molecular aspects; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Carcinogenesis -- Molecular aspects; Biomedicine; Cancer Research; Oncology; Molecular Medicine; Cytokines and Growth Factors; Gene Expression; Carcinogenesis; Medical -- Oncology; Science -- Life Sciences -- Biology -- Molecular Biology; Science -- Life Sciences -- Biochemistry; Medical -- Genetics; Oncology; Medical research; Cellular biology (cytology); Medical genetics; Oncology; Oncology ; Cytokines; Gene expression; Electronic books
• Languages: English
• ISBNs: 9783319536613; 3319536613; 3319536605; 9783319536606
• Related ISBNs: 9783319536606
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed June 7, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.