Proteomic methods in neuropsychiatric research. ([2017])

• Record Type: Book
• Further Information: Note: Paul C. Guest, editor.
• Editors: Guest, Paul C
• Contents: Preface -- Proteomic studies in psychiatric disease and neurological disorders -- Part 1: REVIEWS -- Application of proteomic techniques for improved stratification and treatment of schizophrenia patients -- Multiplexing biomarker methods, proteomics and considerations for Alzheimer's disease -- What have proteomic studies taught us about novel drug targets in autism? -- Application of proteomic approaches to accelerate drug development for psychiatric disorders -- Proteomic biomarker identification in cerebrospinal fluid for leptomeningeal metastases with neurological complications -- Connecting brain proteomics with behavioural neuroscience in translational animal models of neuropsychiatric disorders -- LC-MSE for qualitative and quantitative proteomicstudies of psychiatric disorders -- The utility of multiplex assays for identification of proteomic signatures in psychiatry -- Part 2: PROTOCOLS -- Blood sampling and preparation procedures for proteomic biomarker studies of psychiatric disorders -- Multiplex immunoassay profiling of serum in psychiatric disorders -- Sequential immunopreciptation of secretory vesicle proteins from biosynthetically-labelled cells -- 2d gel electrophoresis of insulin secretory granule proteins from biosynthetically-labelled pancreatic islets -- Two-dimensional gel electrophoresis: a reference protocol -- A two-dimensional difference gel electrophoresis (2D-DIGE) protocol for studies of neural precursor cells -- Identifying biomarker candidates in the blood plasma or serum proteome -- Selective reaction monitoring mass spectrometry for quantitation of glycolytic enzymes in post-mortem brain samples -- A selected reaction monitoring mass spectrometry protocol for validation of proteomic biomarker candidates in studies of psychiatric disorders -- Application of iTRAQ shotgun proteomics for measurement of brain proteins in studies of psychiatric disorders -- Co-immunoprecipitation for deciphering protein interactomes -- Sequential co-immunopreciptation and immunoblot approach to determine oligomerisation of G-protein coupled receptors -- A protocol for producing the maternal low protein rat model: a tool for pre-clinical proteomic studies -- A clinical study protocol to identify serum biomarkers predictive of response to antipsychotics in schizophrenia patients -- Generation of the acute phencyclidine rat model for proteomic studies of schizophrenia A protocol for generation of a corticosterone model of psychiatric disorders -- MK-801-treated oligodendrocytes as a cellular model to study schizophrenia -- Combining patient-reprogrammed neural cells and proteomics as a model to study psychiatric disorders -- SILAC mass spectrometry profiling: a psychiatric disorder perspective -- Preparation of peripheral blood mononuclear cells (PBMCs) as a model for proteomic studies psychiatric disorders -- Proteomic profiling of skin fibroblasts as a model of schizophrenia Proteomic profiling of the pituitary gland in studies of psychiatric disorders -- Development of an assay for measuring proprotein-conversion activity on a multiplex magnetic bead-based array platform -- Phenotyping multiple subsets of immune cells in situ in formalin-fixed, paraffin-embedded tissue sections -- Lab-on-a-chip proteomic assays for psychiatric disorders -- Development of a user-friendly app for testing blood coagulation status in schizophrenia patients -- Part 3:FUTURE PERSPECTIVES -- Proteomic approaches to enable point-of-care testing and personalized medicine for psychiatric disorders.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource, illlustrations
• Subjects: 616.890072; Life sciences; Neuropsychiatry -- Research -- Methodology; Proteomics; Biochemical markers; Gene expression; Gene therapy; Neuropsychiatry -- methods; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Biochemical markers; Proteomics; Medical -- Genetics; Medical genetics; Science -- Life Sciences -- Biochemistry; Proteins; Electronic books
• Languages: English
• ISBNs: 9783319524795; 3319524798; 9783319524788
• Related ISBNs: 331952478X; 9783319524788
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed April 05, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.