Proteomics in Human Reproduction : Biomarkers for Millennials /: Biomarkers for Millennials. (2016)

• Record Type: Book
• Further Information: Note: Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam and Paula Intasqui.
• Other Names: Agarwal, Ashok; Samanta, Luna; Bertolla, Ricardo P; Durairajanayagam, Damayanthi; Intasqui, Paula
• Contents: Foreword; Preface; Contents; About the Authors ; List of Figures; List of Tables; 1 Introduction; 1.1 Human Reproduction and the Current State of Infertility; 1.2 The Reproductive Time Line; 1.3 Biomarkers in Medicine; 1.4 Challenges in Fertility Evaluation and the Role of Biomarkers; 1.5 Use of Omics to Discover Molecular Biomarkers; 1.6 Proteomics as a Promising Tool for Biomarker Discovery; 1.7 Proteomics in Human Reproduction Research and Its Clinical Application; 2 Proteomics; 2.1 Introduction; 2.2 Methods Used in Proteomics; 2.3 Sample Preparation. 2.4 Identification of Proteins Using Mass Spectrometry2.5 Quantitative Proteomics; 2.6 Differentially Expressed Proteins; 2.7 Proteomic Identification of Post-translational Modifications (PTMs); 2.8 Interpretation of Protein Profiles Using Bioinformatics; 2.9 Validation of Mass Spectrometry Data; 2.10 Final Remarks; 3 Proteomics and Male Infertility; 3.1 The Journey of the Human Sperm: From Formation to Fertilization; 3.2 Spermatozoa as One of the Key Players of Reproduction-A Proteomic Approach; 3.3 Seminal Plasma as a Promising Source of Biomarkers of Male Infertility. 3.4 Proteomics in Various Infertility Conditions and Their Possible Biomarkers3.4.1 Azoospermia; 3.4.2 Varicocele; 3.4.3 Proteomic Profiling with Other Conditions of Altered Semen Parameters; 3.4.4 Unexplained Male Infertility; 3.4.5 Semen Oxidative Stress; 3.4.6 Other Infertility Conditions; 4 Role of Proteomics in Female Infertility; 4.1 An Overview on the Physiological Scenario of Female Reproductive Function; 4.2 Mature Murine Oocyte as a Reference for Understanding Human Oocyte Maturation; 4.3 Follicular Fluid as a Biomarker of Oocyte Health and Quality. 4.4 Evaluation of Uterine Status for Successful Implantation4.5 Proteomic Analysis of the Cervical-Vaginal Fluid as a Standard Diagnostic Tool; 4.6 Proteomics in Various Infertility Conditions and Their Possible Biomarkers; 4.7 Endometriosis; 4.8 Polycystic Ovary Syndrome; 4.9 Unexplained Infertility; 5 Proteomics in Assisted Reproduction; 5.1 Proteomics of Embryos: Lessons from Animal Studies; 5.2 Noninvasive Proteome Prediction of Human Embryo; 5.3 Proteome Biomarkers of the Embryo; 5.4 Endometrium; 6 Challenges of Proteomic Studies in Human Reproduction; 6.1 Goals and Challenges. 6.2 Sample Complexity6.3 Mass Spectrometry Analysis; 6.4 Protein Quantitation; 6.5 Post-translational Modifications; 6.6 Data Analysis; 7 What Does the Future Hold; 7.1 Benefits/Advantages of Proteomics in Reproductive Medicine; 7.2 Dealing with Limitations in the Use of Proteomics in the Field of Reproduction; 7.3 Translating Findings into a Clinical Setting; 7.4 Systems Biology and the Omics Cascade; 7.5 Final Remarks; 8 Conclusions; References.
• Publisher Details: Place of publication not identified : Springer Science and Business Media Springer
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 610; Medicine; Reproductive health; Proteomics; Bioinformatics; Reproductive Medicine; HEALTH & FITNESS -- Holism; HEALTH & FITNESS -- Reference; MEDICAL -- Alternative Medicine; MEDICAL -- Atlases; MEDICAL -- Essays; MEDICAL -- Family & General Practice; MEDICAL -- Holistic Medicine; MEDICAL -- Osteopathy; Bioinformatics; Medicine; Proteomics; Reproductive health; Science -- Life Sciences -- Biochemistry; Science -- Life Sciences -- Anatomy & Physiology; Proteins; Molecular biology; Health & Fitness -- Diseases -- Genetic; Reproductive medicine; Electronic books
• Languages: English
• ISBNs: 3319484184; 9783319484181; 3319484168; 9783319484167
• Related ISBNs: 9783319484167
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.