Metabolism in cancer. (2016)

• Record Type: Book
• Further Information: Note: Thorsten Cramer, Clemens A. Schmitt, editors.
• Editors: Cramer, Thorsten; Schmitt, Clemens
• Contents: Contributors; Description and Purpose of the Work; 1 The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells; Abstract; 1 Glucose Metabolism in Cancer Cells; 2 Lipid Metabolism in Cancer Cells; 3 The Cost of Increased Lipid Biosynthesis in Cancer Cells; 4 Lipid Uptake and Remodelling in Cancer; 5 Concluding Remarks; References; 2 Lactate-An Integrative Mirror of Cancer Metabolism; Abstract; 1 Introduction; 2 Metabolic Reprogramming in Malignant Tumors; 3 The imBI Technique; 4 Representativeness of One Versus Multiple Biopsies 5 Metabolic Asservation in Liquid Nitrogen6 Metabolic Imaging with ImBI in Rectum Cancer; 7 Conclusions; Acknowledgments; References; 3 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer; Abstract; 1 Introduction; 2 Signaling Through the PI3K-Akt-mTOR Pathway; 2.1 PI3K-Akt Pathway Activation; 2.2 Downstream Effectors; 2.2.1 Post-translational Modulation; 2.2.2 Transcriptional Output; FoxO; c-Myc; HIFs; SREBPs; 3 The PI3K-Akt-mTOR Pathway Regulates Glucose Metabolism and the Warburg Effect; 3.1 Glucose Uptake; 3.1.1 Glucose Uptake in the Clinic; 3.2 Regulation of Glycolytic Enzymes 4 Beyond Aerobic Glycolysis: Coordination with Anabolic Metabolism4.1 Pentose Phosphate Pathway; 4.2 Nucleotide Biosynthesis; 4.3 Lipid Synthesis; 4.4 Glutamine Metabolism; 5 Concluding Remarks; References; 4 MYC, Metabolic Synthetic Lethality, and Cancer; Abstract; 1 Background; 2 Regulation of MYC and Its Function; 3 MYC Target Genes and Metabolism; 4 MYC, Protein Synthesis, and Ribosomal Biogenesis; 5 MYC Metabolic Synthetic Lethal Interactions and Therapy; 6 Concluding Remarks; References; 5 The Role of pH Regulation in Cancer Progression; Abstract; 1 Introduction 1.1 Measurements of Intracellular and Extracellular Tumour pH2 Why Are Tumours Acidic?; 2.1 pH Sensing; 2.2 Mechanisms of pH Regulation; 3 Lactate Acid Secretion (Monocarboxylate Transporters 1-4); 4 Sodium Hydrogen Ion Exchangers (NHE); 5 Vacuolar-Type H+ ATPase; 6 Extracellular Membrane-tethered Carbonic Anhydrases (CAIX/CAXII); 7 Bicarbonate Transporters; 8 Metabolons; 8.1 pH and Cell Phenotype; 8.1.1 Proliferation and Growth; 9 The Effect of pH on Migration and Metastasis; 10 The Expression of PH Regulators and Metastasis 11 Functional Studies of pH Regulators and Their Effects on Migration and Metastasis12 Therapeutic Considerations; 12.1 The Effects of pH on Chemotherapy and Radiotherapy; 13 pH Modulators as Therapeutic Targets; 14 Conclusion; Acknowledgments; References; 6 Metabolic Features of Cancer Treatment Resistance; Abstract; 1 Overview of Tumor Resistance: Old Concepts and New Foes; 2 Metabolism of Treatment-Resistant Cells; 3 Therapeutic Implications; 4 Autophagy, Mitochondrial Respiration, and Tumor Stem Cells: The Ultimate Theory of Tumor Resistance; Acknowledgments; References
• Publisher Details: Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource (ix, 266 pages), illustrations (some color)
• Subjects: 616.99/4; Medicine; Cancer -- Molecular aspects; Metabolism; Oncology ; Immunology; Biochemistry; Cytology; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Cancer -- Molecular aspects; Metabolism; Medical -- Immunology; Science -- Life Sciences -- Biochemistry; Science -- Life Sciences -- Biology -- Molecular Biology; Immunology; Biochemistry; Cellular biology (cytology); Medical -- Oncology; Oncology; Neoplasms -- metabolism; Electronic books
• Languages: English
• ISBNs: 9783319421186; 3319421182
• Related ISBNs: 9783319421162; 3319421166
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed August 31, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.