Childhood acute lymphoblastic leukemia. (2017)

• Record Type: Book
• Further Information: Note: Ajay Vora, editor.
• Editors: Vora, Ajay
• Contents: Contributors; Chapter 1: Epidemiology and Etiology of Childhood ALL; 1.1 Introduction; 1.2 General Epidemiology; 1.3 Natural History; 1.4 Environmental Risk Factors; 1.4.1 Infectious Disease and Immune Stimulation; 1.4.2 Other Risk Factors; 1.5 Heritability of ALL; 1.6 High-Penetrance Genetic Predisposition; 1.6.1 Syndromes Where ALL Is a Dominant Cancer Phenotype; 1.6.2 Syndromes Where ALL Is Part of a Mixed Cancer Phenotype; 1.7 Low-Penetrance Genetic Predisposition; 1.8 Future Directions; References; Chapter 2: Clinical Presentation and Prognostic Factors. 2.1 Clinical Presentation2.1.1 Introduction; 2.1.2 Symptoms and Signs Related to Bone Marrow Involvement; 2.1.3 Symptoms and Signs Related to Extensive Bulk Disease; 2.1.4 Central Nervous System; 2.1.5 The Eye; 2.1.6 Genitourinary System; 2.1.7 Cardiovascular System; 2.1.8 The Skin; 2.1.9 Head and Neck; 2.1.10 Gastrointestinal System; 2.1.11 Hypercalcaemia; 2.1.12 Haemophagocytic Lymphohistiocytosis (HLH); 2.1.13 Aplastic Presentation; 2.1.14 Rare Presentations; 2.1.15 Asymptomatic Pancytopenia; 2.1.16 The Diagnostic Interval and Pathway; 2.1.17 Differential Diagnosis; 2.2 Laboratory Features. 2.2.1 Haematology2.2.2 Biochemistry; 2.2.3 Bone Marrow Aspirate; 2.2.4 Lumbar Puncture; 2.3 Diagnostic Workup; 2.4 Prognostic Factors; 2.5 Individual Prognostic Factors; 2.5.1 Age; 2.5.2 White Cell Count; 2.5.3 NCI Risk Score; 2.5.4 Gender; 2.5.5 CNS Disease; 2.5.6 Disease Bulk; 2.5.7 Immunophenotype; 2.5.8 Genetics; 2.5.9 Response to Treatment; References; Chapter 3: Diagnostic Flow Cytometry and Immunophenotypic Classification; 3.1 Introduction; 3.2 Immunophenotype of T-Lymphoblastic Leukemia/Lymphoma; 3.3 Early T-Cell Precursor ALL; 3.4 Immunophenotype of B-Lymphoblastic Leukemia/Lymphoma. 3.5 Acute Leukaemia of Ambiguous Lineage3.6 Antigen Expression: Correlation to Prognosis and Cytogenetics; 3.7 Extended Leukaemia Immunophenotyping; 3.8 Conclusions and Perspective; References; Chapter 4: Cytogenetics and Molecular Genetics; 4.1 Introduction; 4.2 Abnormality Detection Methodologies; 4.3 Chromosomal Abnormalities in BCP-ALL; 4.3.1 Favourable Risk Abnormalities; 4.3.1.1 High Hyperdiploidy; 4.3.1.2 t(12; 21)(p13; q22)/ETV6-RUNX1; 4.3.1.3 t(1; 19)(q23; p13)/TCF3-PBX1; 4.3.2 Poor-Risk Chromosomal Abnormalities; 4.3.2.1 t(9; 22)(q34; q11.1)/BCR-ABL1; 4.3.2.2 t(17; 19)(q22. P13)/TCF3-HLF4.3.2.3 11q23/KMT2A Gene Rearrangements; 4.3.2.4 Near-Haploidy and Low Hypodiploidy; 4.3.2.5 Intrachromosomal Amplification of Chromosome 21 (iAMP21); 4.3.3 B-ALL Lacking Sentinel Chromosomal Rearrangements; 4.3.3.1 Ph-Like or BCR-ABL1-Like ALL; 4.3.3.2 CRLF2 Rearrangements and Janus Kinase Mutations in ALL; 4.3.3.3 DUX4 and ERG-Deregulated ALL; 4.3.3.4 Translocations Involving the IGH Locus; 4.3.3.5 PAX5 Rearrangements; MEF2D and ZNF384 Gene Fusions; ETV6-RUNX1-Like; 4.3.4 Secondary Genetic Alterations in BCP-ALL; 4.4 Genetic Rearrangements in T-Lineage ALL.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource (ix, 342 pages), illustrations (some color)
• Subjects: 618.92/99419; Medicine; Lymphoblastic leukemia in children; Lymphoblastic leukemia in children -- Diagnosis; Lymphoblastic leukemia in children -- Treatment; MEDICAL -- Gynecology & Obstetrics; Lymphoblastic leukemia in children; Medicine & Public Health; Hematology; Pediatrics; Oncology; Medical -- Pediatrics; Medical -- Oncology; Paediatric medicine; Oncology; Hematology; Pediatrics; Oncology ; Medical -- Hematology; Haematology; Electronic books
• Languages: English
• ISBNs: 9783319397085; 3319397087
• Related ISBNs: 9783319397078; 3319397079
• Notes: Note: Includes bibliographical references at the end of each chapters and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed April 27, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.