Apoptosis in cancer pathogenesis and anti-cancer therapy : new perspectives and opportunities /: new perspectives and opportunities. (2016)

• Record Type: Book
• Further Information: Note: Christopher D. Gregory, editor.
• Editors: Gregory, Christopher D
• Contents: Foreword; Preface; Acknowledgements; Contents; Contributors; Chapter 1: Molecular Cell Biology of€Apoptosis and€Necroptosis in€Cancer; 1.1 Introduction; 1.2 Role of€Cell Death Pathways in€Cancer Suppression; 1.3 Apoptosis; 1.3.1 Caspases and€Cell Death; 1.3.2 Intrinsic Cell Death; 1.3.2.1 Mechanisms of€Caspase-9-Mediated Apoptosis; 1.3.2.2 Physiological Functions of€the€Mitochondrial Apoptotic Pathway; 1.3.2.3 Mitochondrial Apoptotic Pathway in€Cancer and€Cancer Therapy; 1.3.2.4 Mechanisms of€Caspase-2-Mediated Apoptosis; 1.3.2.5 Physiological Functions of€the€Caspase-2 Apoptosis Pathway. 1.3.2.6 Caspase-2-Mediated Apoptosis in€Cancer and€Cancer Therapy1.3.3 Extrinsic Cell Death; 1.3.3.1 Physiological Functions of€the€Caspase-8 Apoptosis Pathway; 1.3.3.2 Caspase-8-Mediated Apoptosis in€Cancer and€Cancer Therapy; 1.3.4 RIPK-Mediated Necroptosis: A€New Target for€Tumor Therapy?; 1.3.4.1 Mechanisms of€Necroptosis; 1.3.4.2 Physiological Role of€RIPK-Mediated Necroptosis; 1.3.4.3 Necroptosis in€Cancer and€Cancer Therapy; 1.3.5 Perspectives; References; Chapter 2: Clearance of€Dying Cells by Phagocytes: Mechanisms and€Implications for€Disease Pathogenesis; 2.1 Introduction. 2.2 Types of€Apoptotic Cells and€Phagocytes2.3 Steps in€Apoptotic Cell Engulfment; 2.3.1 Find-Me Signals; 2.3.2 Eat-Me Signals; 2.3.3 The Engulfment Receptors and€Bridging Molecules; 2.3.4 Intracellular Signaling in€the€Phagocyte; 2.4 Effects of€Apoptotic Cell Clearance; 2.4.1 Induction of€an€Anti-inflammatory Program; 2.4.2 Suppression of€Proinflammatory Signals; 2.5 Defective Apoptotic Cell Clearance and€Inflammatory Disease; 2.5.1 Autoimmunity; 2.5.2 Airway Inflammation; 2.5.3 Inflammatory Colitis; 2.6 Phagocytes, Anti-inflammatory Responses, and€Cancer Context. 2.6.1 Phagocytic Signaling Pathways in€a€Malignant Tissue2.6.2 BAI1; 2.6.3 ELMO1; 2.6.4 Pannexin Channels; 2.6.5 MER Tyrosine Kinase; 2.7 Concluding Thoughts; References; Chapter 3: Microenvironmental Effects of€Cell Death in€Malignant Disease; 3.1 Introduction: Imbalances of€Cell Birth and€Cell Death in€Cancer; 3.2 A Poisoned Chalice: Tumor-Promoting as€well as Tumor-ƯSuppressing Roles of€Apoptosis; 3.3 Cell Death Modalities Influencing the€Tumor Microenvironment: Apoptosis and€Other Mechanisms; 3.3.1 Triggering of€Apoptosis in Growing Tumors; 3.3.2 Necrosis, Autophagy, and€Other Mechanisms. 3.4 Biological Activities of€Apoptotic Tumor Cells3.4.1 Mechanisms; 3.4.2 Activities of€Stressed Cells Versus Dying Cells; 3.5 Responses to€Cell Death in€the€Tumor Microenvironment; 3.6 Apoptosis and€Angiogenesis: The€Effects of€Hypoxia; 3.7 Apoptosis and€Tissue Repair Mechanisms in€Cancer: The€"Onco-Regenerative Niche"; 3.8 Opportunities for€Improving Cancer Treatment; 3.9 Conclusions and€Future Perspectives; References; Chapter 4: Apoptotic Caspases in€Promoting Cancer: Implications from€Their Roles in€Development and€Tissue Homeostasis; 4.1 Introduction.
• Publisher Details: Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource (xvii, 247 pages), illustrations (some color)
• Subjects: 571.9/36; Medicine; Apoptosis; Cancer -- Treatment; SCIENCE -- Life Sciences -- Anatomy & Physiology; Apoptosis; Cancer -- Treatment; Apoptosis; Science -- Life Sciences -- Cytology; Science -- Life Sciences -- Biology -- Molecular Biology; Cellular biology (cytology); Medical research; Oncology; Cytology; Medical -- Oncology; Oncology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319394060; 3319394061
• Related ISBNs: 9783319394046; 3319394045
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed September 1, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.