The initiation of DNA replication in eukaryotes. ([2016])

• Record Type: Book
• Further Information: Note: Daniel L. Kaplan, editor.
• Authors: Kaplan, Daniel L
• Editors: Kaplan, Daniel L
• Contents: 1. Introduction to DNA replication initiation in eukaryotes -- 2. Choice of origins and replication timing control in yeast -- 3. Replication timing and initiation in metazoans.- 4. Replication timing gradients and origin activation -- 5. Genome wide localization of replication initiation factors -- 6. Genome scale analysis of metaozoan replication origins -- 7. Role of dormant origins in replication initiation -- 8. Centromeres and DNA replication initiation -- 9. Rif1 regulation of replication timing -- 10. Role of ORC in replication initiation.- 11. Licensing of replication origins- loading Mcm2-7 -- 12. Role of chromatin in replication initiation -- 13. Role of Mcm2-7 in replication initiation -- 14. Role of CDK in replication initiation -- 15. Role of DDK in replication initiation -- 16. Roles of Sld2, Sld3, and Dpb11 in replication initiation -- 17. Role of Mcm10 in replication initiation -- 18. Role of post-translational modifications in replication initiation -- 19. Assembly of the Cdc45-Mcm2-7-GINS complex, the replication helicase.- 20. Activity of the Cdc45-Mcm2-7-GINS complex, the replication helicase -- 21. Structure function studies of replication initiation factors -- 22. Pol-alpha activation and coupling with helicase unwinding -- 23. Replication initiation and DNA damage -- 24. Protein phosphatases and replication initiation -- 25. Spindle checkpoints and replication initiation.- 26. Protein degradation and replication initiation -- 27. Break-induced replication.- 27. Meier Gorlin syndrome -- 28. Replication Stress and Cancer.
• Publisher Details: Cham : Springer
• Publication Date: 2016
• Copyright Date: 2016
• Extent: 1 online resource, color illustrations
• Subjects: 571.6; Medicine; Eukaryotic cells; Cytology; Molecular biology; SCIENCE -- Life Sciences -- Anatomy & Physiology; Cytology; Eukaryotic cells; Molecular biology; DNA Replication -- physiology; Eukaryotic Cells -- physiology; Science -- Life Sciences -- General; Science -- Life Sciences -- Biology -- Microbiology; Life sciences: general issues; Microbiology (non-medical); Human genetics; Biological models; Microbial genetics; Microbial genomics; Medical -- Genetics; Medical genetics; Electronic books
• Languages: English
• ISBNs: 9783319246963; 3319246968; 3319246941; 9783319246949
• Related ISBNs: 9783319246949
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (Ebsco, viewed February 16, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.