Resistance of cancer cells to CTL-mediated immunotherapy. (2015)

• Record Type: Book
• Further Information: Note: Benjamin Bonavida, Salem Chouaib, editors.
• Editors: Bonavida, Benjamin; Chouaib, S (Salem)
• Contents: Preface; Acknowledgements; Contents; Part I: Factors Regulating Resistance to CTL Cytotoxicity; Chapter 1: Resistance of Cancer Stem Cells to Cell-­Mediated Immune Responses; 1.1 Introduction; 1.2 CSCs Markers; 1.3 Survival Pathways in CSCs; 1.4 Immunological Profile of CSCs; 1.5 Expression of TAAs by CSCs; 1.6 Cell-Mediated Immune Responses Against CSCs and Immune Escape Mechanisms; 1.7 Immunoregulatory/Immune Escape Mechanisms Associated with CSCs; 1.8 Conclusions; References; Chapter 2: Role of Co-inhibitory Molecules in Tumor Escape from CTL Attack; 2.1 Introduction; 2.2 CTL Activation. 2.3 Tumor-Associated Antigens2.4 Allogeneic Stem Cell Transplantation; 2.5 Adoptive T-Cell Transfer; 2.6 Co-inhibitory Molecules in Cancer; 2.6.1 PD-1; 2.6.1.1 Expression and Function of PD-1; 2.6.1.2 PD-1 in Cancer; 2.6.2 CTLA-4; 2.6.2.1 Expression and Function of CTLA-4; 2.6.2.2 CTLA-4 in Stem Cell Transplantation; 2.7 Combining PD-1 and CTLA-4 Blockade; 2.8 BTLA; 2.8.1 Expression and Function of BTLA; 2.8.2 Tim-3; 2.8.3 LAG3; 2.9 Other Co-inhibitory Players; 2.10 Future Prospects; References; Chapter 3: Role of the Non-classical HLA Class I Antigens for Immune Escape; 3.1 Introduction. 3.1.1 Features of HLA-G3.1.2 HLA-G and Immune Responses; 3.1.3 Regulation of HLA-G Expression; 3.1.4 Pathophysiologic Expression of HLA-G in Human Tumors; 3.1.5 Clinical Significance of HLA-G in Solid and Hematopoietic Tumors; 3.1.6 Modulation of HLA-G in Tumors; 3.1.7 Altered Immune Response of HLA-G+ Tumors; 3.1.8 Other Roles of HLA-G; 3.1.9 HLA-G as Therapeutic Target; 3.2 Conclusion; References; Chapter 4: Integrins: Friends or Foes of Antitumor Cytotoxic T Lymphocyte Response; 4.1 Introduction; 4.2 Integrins Are Major Regulators of T-Cell Functions. 4.3 CD103 Integrin: A Key Asset for CTL Functional Activities in Epithelial Tumors4.4 Protumoral Effects of Certain Integrin Members; 4.5 Altered Expression of Integrins and Integrin Ligands Contributes to Tumor Escape from CTL Response; 4.6 Conclusion; References; Chapter 5: Cytotoxic T Lymphocytes and Their Granzymes: An Overview; 5.1 Introduction; 5.2 Origin and Maturation of Cytotoxic T Lymphocytes; 5.3 Activation of Cytotoxic T Lymphocytes; 5.4 Effector Mechanisms of Cytotoxic T Lymphocytes; 5.5 Extracellular Roles of Granzymes; 5.6 Concluding Remarks; References. Part II: Influence of the Tumor Microenvironment on the Resistance to CTL CytotoxicityChapter 6: Hypoxia: A Formidable Saboteur of the Anti-­tumor Response; 6.1 The CTL in the Context of Microenvironmental Hypoxia; 6.2 Hypoxia as a Major Component of the Tumor Microenvironment; 6.3 Hypoxic Stress and T Cells; 6.3.1 Hypoxia Interferes with the CTL Response; 6.3.2 Hypoxic Stress Impacts Immune Suppression; 6.3.3 Hypoxia Influences Tumor Vessel Normalization and T Cell Migration; 6.4 Hypoxic Stress and Tumor Target Plasticity; 6.4.1 Tumor Cell Heterogeneity: Cancer Stem Cells.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Extent: 1 online resource (xiv, 353 pages), illustrations (some color)
• Subjects: 616.99/406; Medicine; Drug resistance in cancer cells; Cancer -- Immunotherapy; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cancer -- Immunotherapy; Drug resistance in cancer cells; Drug Resistance, Neoplasm; Medical -- Pharmacology; Science -- Life Sciences -- Biology -- Molecular Biology; Pharmacology; Medical research; Oncology; Drug interactions; Medical -- Oncology; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319178073; 3319178075; 3319178067; 9783319178066
• Related ISBNs: 9783319178066
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed June 24, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.