Progranulin : Methods and Protocols /: Methods and Protocols. (2018)

• Record Type: Book
• Further Information: Note: Andrew Bateman, Hugh P.J. Bennett, Siu Tim Cheung.
• Editors: Bateman, Andrew; Bennett, Hugh P. J; Cheung, Siu Tim
• Contents: Preface…Table of Contents…Contributing Authors…Part I Introduction1. A Brief Overview of Progranulin in Health and DiseaseAndrew Bateman, Siu Tim Cheung, and Hugh P.J. BennettPart II Analytical and In Vitro Methods for the Study of Progranulin Biology2. Chromatographic Methods for the Purification of Granulin PeptidesAndrew Bateman, Babykumari Chitramuthu, and Hugh P.J. Bennett3. Methods for Expression and Purification of Biologically Active Recombinant ProgranulinChun Yu Zhao and Andrew Bateman4. Large-Scale Generation of Recombinant Granulin Peptides in E. coliDmitri Tolkachev5. Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine BridgingDmitri Tolkatchev6. Data Mining: Applying the AD&FTD Mutation Database to ProgranulinMarc Cruts and Christine Van BroeckhovenPart III Methods to Investigate the Role of Prgranulin in Cancer7. Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human DiseasesGinette Serrero and David Hicks8. Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic BiomarkerGinette Serrero and David Hicks9. Analysis of Progranulin-Mediated Akt and MAPK ActivationShi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonio Belfiore, Renato V. Iozzo, and Andrea Morrione10. Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer ModelsChi Wai Yip, Phyllis F.Y. Cheung, Nicholas C.L. Wong, Sze Wai Fung, and Siu Tim Cheung11. Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell FeaturesPhyllis F.Y. Cheung and Siu Tim Cheung12. Methods to Study the Role of Progranulin in the Tumor MicroenvironmentMoshe Elkabets and Samuel BrookPart IV Animal Models to Study the Role of Progragulin in Health and Disease13. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegansJames Julian Doyle and J. Alex Parker14. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress ResponseTsung-Yuan Hsu, Victoria J. Butler, and Aimee W. Kao15. Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal FunctionBabykumari P. Chitramuthu and Hugh P.J. Bennett16. Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout MiceJan Boddaert, Hans Wils, and Samir Kumar-Singh17. Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the BrainJackalina M. Van Kampen18. The Interaction between Progranulin with Sortilin and the LysosomeXiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu19. Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo DevelopmentLaura Diaz-Cueto, Fabian Arechavaleta-Velasco, and George L. Gerton20. Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory ArthritisJian-Iu Wei and Chuan-ju Liu21. Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro StudiesTohru Ohama, Ryota Kawase, Yasushi Sakata, and Shizuya Yamashita22. Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse ModelsHuishi Toh, Eugene Daniels, and Andrew Bateman.
• Publisher Details: New York : Humana Press
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource (363 pages)
• Subjects: Life sciences; Biochemistry; Science -- Life Sciences -- Biochemistry; Proteins
• Languages: English
• ISBNs: 9781493985593
• Related ISBNs: 9781493985579
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.