Discoidin domain receptors in health and disease. (2016)

• Record Type: Book
• Further Information: Note: Rafael Fridman, Paul H. Huang, editors.
• Editors: Fridman, Rafael; Huang, Paul H
• Contents: Preface; Contents; Contributors; Part I: Discoidin Domain Receptor Biology and Roles in Physiology; Chapter 1: DDRs: Binding Properties, Cell Adhesion and€Modulation of€Integrin Function; 1.1 Introduction; 1.2 DDR Binding Properties; 1.2.1 DDR Domain Organization; 1.2.2 Collagen Structure; 1.2.3 Ligand-Binding Specificity of€the€DDRs; 1.2.4 DDR Binding Sites in€Collagen; 1.2.5 Molecular Basis of€Collagen Binding; 1.3 DDR Functions in€Cell Adhesion and€Migration; 1.4 Cooperation of€the€DDRs with€Integrins; 1.5 Conclusions; References; Chapter 2: DDRs and€Collagen Fibrillogenesis. 2.1 Introduction2.2 DDRs andCollagen Fibrillogenesis; 2.3 Fibrillogenesis ofCollagen Type I; 2.3.1 Collagen Biosynthesis; 2.3.2 Propeptide Cleavage; 2.3.3 Interaction ofDDRs withTropocollagen; 2.3.4 Collagen Microfibril; 2.3.5 Cell Surface; 2.3.6 Collagen Fibril; 2.3.7 Role ofGlycosylation; 2.3.8 Collagen Cross-Linking; 2.4 Functional Consequences; 2.4.1 Cell--Matrix Interactions; 2.4.2 Matrix Mineralization; 2.4.3 Matrix Mechanics; 2.5 Other Collagen Types; 2.6 Conclusions; References; Chapter 3: DDR Structural Biology; 3.1 Introduction; 3.1.1 Structure oftheDS Domain. 3.1.2 Structure of€the€DS-Like Domain3.1.3 Collagen Recognition of€the€DS Domain; 3.1.4 Convergent Evolution of€GVMGFO-Binding Sites; 3.2 Transmembrane and€Intracellular Domains; 3.3 Perspectives; References; Chapter 4: DDR Mouse Models; 4.1 Introduction; 4.2 Body Size; 4.2.1 DDR1-Deficient Mice; 4.2.2 DDR2-Deficient Mice; 4.2.3 Smallie: DDR2-Deficient Mutant Mice; 4.2.4 Dominant-Negative DDR2 Transgenic Mice; 4.2.5 DDR2-Overexpressing Transgenic Mice; 4.3 Reproduction; 4.3.1 Implantation in€DDR1-Deficient Mice; 4.3.2 Mammary Glands in€DDR1-Deficient Mice; 4.3.3 Ovaries in€Smallie Mice. 4.3.4 Testes in€Smallie Mice4.4 Skin Wound Healing; 4.5 Osteoarthritis; 4.5.1 Osteoarthritis in€DDR2-Deficient Mice; 4.5.2 Osteoarthritis in€DDR1-Deficient Mice; 4.6 Atherosclerosis; 4.7 Fibrosis; 4.7.1 Lung Fibrosis; 4.7.2 Kidney Fibrosis; 4.7.3 Liver Fibrosis; 4.8 Auditory Sensation; 4.9 Heart Structure and€Function; 4.10 Conclusion; References; Chapter 5: Discoidin Domain Receptors in€Invertebrates; 5.1 Evolutionary Origin and€Distribution of€Discoidin Domain Receptors in€Invertebrates; 5.2 Discoidin Domain Receptors in€C. elegans; 5.2.1 The C. elegans Nervous System. 5.2.2 Discoidin Domain Receptor Expression in€C. elegans5.2.3 C. elegans DDRs Function in€the€Guidance of€Axons Along€Longitudinal Nerve Tracts; 5.3 Collagens as€Putative Ligands for€DDRs in€C. elegans; References; Part II: Discoidin Domain Receptors in Cancer; Chapter 6: Discoidin Domain Receptors and€Disease; 6.1 DDRs and€Development; 6.2 DDRs and€Atherosclerosis; 6.3 DDRs and€Arthritis; 6.4 DDRs and€Fibrosis; 6.5 DDRs and€Cancer; 6.5.1 DDRs Expression in€Cancer; 6.5.2 Tumor Cell Adhesion; 6.5.3 Tumor Cell Invasion and€Migration.
• Publisher Details: New York : Springer
• Publication Date: 2016
• Extent: 1 online resource (xiv, 355 pages), illustrations (some color)
• Subjects: 572/.696; Medicine; Cell receptors; SCIENCE -- Life Sciences -- Biochemistry; Cell receptors; Receptors, Cell Surface; Medical -- Microbiology; Medical -- Biochemistry; Science -- Life Sciences -- Biology -- Molecular Biology; Medical microbiology & virology; Biochemistry; Cellular biology (cytology); Oncology; Microbiology; Biochemistry; Cytology; Medical -- Oncology; Oncology; Electronic books
• Languages: English
• ISBNs: 9781493963836
• Related ISBNs: 149396383X; 9781493963812; 1493963813
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed August 19, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.