Phenotypes and genotypes : the search for influential genes /: the search for influential genes. (2016)

• Record Type: Book
• Further Information: Note: Florian Frommlet, Małgorzata Bogdam, David Ramsey.
• Authors: Frommlet, Florian; Bogdan, Malgorzata; Ramsey, David (David Mark)
• Contents: Preface; Contents; Acronyms; 1 Introduction; References; 2 A Primer in Genetics; 2.1 Basic Biology; 2.1.1 Phenotypes and Genotypes; 2.1.2 Meiosis and Crossover; 2.1.3 Genetic Distance; 2.1.4 The Haldane Mapping Function; 2.1.5 Interference and Other Mapping Functions; 2.1.6 Markers and Genetic Maps; 2.2 Types of Study; 2.2.1 Crossing Experiments; 2.2.2 The Basics of QTL Mapping; 2.2.3 Association Studies; 2.2.4 Other Types of Study; References; 3 Statistical Methods in High Dimensions; 3.1 Overview; 3.2 Multiple Testing; 3.2.1 Classical Procedures Controlling FWER. 3.2.2 Permutation Tests and Resampling Procedures3.2.3 Controlling the False Discovery Rate; 3.2.4 Multiple Testing Under Sparsity. Minimizing the Bayesian Risk in Multiple Testing Procedures; 3.3 Model Selection; 3.3.1 The Likelihood Function; 3.3.2 Information Theoretical Approach; 3.3.3 Bayesian Model Selection and the Bayesian Information Criterion; 3.3.4 Modifications of BIC for High-Dimensional Data Under Sparsity; 3.3.5 Further Approaches to Model Selection; References; 4 Statistical Methods of QTL Mapping for Experimental Populations; 4.1 Classical Approaches. 4.1.1 Single Marker Tests4.1.2 Power of a Test Based on a Single Marker as a Function of the Distance Between the Marker and a QTL; 4.1.3 Genome Wide Search with Tests Based on Single Markers; 4.2 Interval Mapping; 4.2.1 Interval Mapping based on the mixture model; 4.2.2 Regression Interval Mapping; 4.2.3 Nonparametric Version of Interval Mapping; 4.2.4 Specific Models; 4.2.5 Overestimation of Genetic Effects; 4.3 Model Selection; 4.3.1 QTL mapping with mBIC; 4.3.2 Robust Version of mBIC; 4.3.3 Version of mBIC Based on Rank Regression; 4.3.4 Extensions to Generalized Linear Models. 4.3.5 mBIC for Dense Markers and Interval Mapping4.4 Logic Regression; 4.5 Applying mBIC in a Bayesian Approach; 4.6 Closing Remarks; References; 5 Statistical Analysis of GWAS; 5.1 Overview; 5.2 Inferring Genotypes; 5.2.1 Genotype Calling; 5.2.2 Imputation; 5.3 Single Marker Tests; 5.3.1 Case-Control Studies; 5.3.2 Quantitative Traits; 5.3.3 Covariates and Population Stratification; 5.3.4 Multiple Testing Correction; 5.3.5 Rare SNPs; 5.4 Model Selection; 5.4.1 Motivation; 5.4.2 HYPERLASSO; 5.4.3 GWASelect; 5.4.4 MOSGWA; 5.4.5 Comparison of Methods; 5.4.6 Mixed Models; 5.5 Admixture Mapping. 5.6 Gene -- Gene Interaction5.6.1 Analyzing Gene -- Gene Interaction via ANOVA; 5.6.2 Multifactor Dimensionality Reduction; 5.6.3 Logic Regression in GWAS; 5.7 Other Recent Advances and the Outlook for GWAS; References; 6 Appendix A: Basic Statistical Distributions; 6.1 Normal Distribution; 6.2 Important Distributions of Sample Statistics; 6.2.1 Chi-Square Distribution; 6.2.2 Student's t-Distribution; 6.2.3 F-distribution; 6.3 Gamma and Beta Distributions; 6.3.1 Exponential Distribution; 6.3.2 Inverse Gamma Distribution; 6.3.3 Beta Distribution; 6.4 Double Exponential Distribution and Extensions.
• Publisher Details: London : Springer
• Publication Date: 2016
• Extent: 1 online resource, illustrations (some color)
• Subjects: 576.5; Computer science; Genetics; Phenotype; SCIENCE -- Life Sciences -- Evolution; Genetics; Phenotype; Genetics; Science -- Life Sciences -- Anatomy & Physiology; Medical -- Biostatistics; Molecular biology; Probability & statistics; Bioinformatics; Statistics; Computers -- Computer Science; Life sciences: general issues; Electronic books
• Languages: English
• ISBNs: 9781447153108; 1447153103; 9781447153092
• Related ISBNs: 144715309X; 9781447153092
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed February 17, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.