Cell therapy : current status and future directions /: current status and future directions. (2017)

• Record Type: Book
• Further Information: Note: Dwaine F. Emerich, Gorka Orive, editors.
• Other Names: Emerich, Dwaine F; Orive, Gorka
• Contents: Encapsulating Islets: Biomass Considerations Islet Encapsulation Failure Modes;Subacute Processing Stress; Acute Implant Failure; Chronic Failure of Cell Encapsulation Systems; Immune Rejection; Hypoxia; Strategies for Addressing Hypoxia; Refillable Gas Supply; Artificial Oxygen Carriers; Vascularization; Strategies for Mitigating Chronic Fibrosis; Coatings and Covalent Modifications; Stem Cell-Derived B-Cells as an Alternative to Isolated Cadaveric Islets; Generation of Glucoresponsive Stem Cell-Derived B-Cells; Clinical Translation of Stem Cell-Derived B-Cells. The Future of B-Cell TherapyReferences; 3: Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases; Introduction; Acute Pathology of Stroke and TBI; Chronic Pathology of Stroke and TBI; Stem Cell Therapy for Neurovascular Disorders; Stem Cell Transplantation in Stroke; Stem Cell Transplantation in TBI; Mechanisms of Stem Cell Therapy; The Promise of Combination Therapies with Stem Cells; The Spleen as a Novel Target for Stem Cells; Challenges in Stem Cell Therapy; Potential Adverse Effects of Stem Cell Therapy; Cell-Free Materials and Exosomes in Neurovascular Therapy. Dedication; Preface: A Brief Introduction to the Span of Cell Therapy; Contents; Contributors; 1: Molecular Considerations in Cell Transplant Imaging; Introduction; The Need for Molecular Imaging: Limitations of Cell-Based Therapies;Recent Advances in Molecular Imaging;Bright-Field and Fluorescent Optical Imaging; PET Imaging; Bioluminescence Imaging; MR Imaging and Spectroscopy; Concluding Remarks and Outlook; References; 2: Considerations for Successful Encapsulated B-cell Therapy; Introduction; Islet Transplantation; Islet Transplantation: Site Selection Considerations. TBI and Stroke: Implications of Cell-Free Treatment Feasibility of Exosome Transplantation Therapies; Conclusion: Connecting the Dots of Stem Cell Therapy; References; 4: Cell Replacement Strategies for Parkinson's Disease; Introduction; Ventral Mesencephalon Grafting; Clinical Trial Outcomes; Stem Cell Grafting; Conclusions; References; 5: Cell Therapy for Epilepsy; Epilepsy; History; Definitions, Clinical Features, Therapeutic Needs, and Models; Cell Therapy: Direct Grafting; Introduction: Cell Types; Substitution Strategies and Bystander Effects. Increased Inhibition Strategies Limits of This Approach; Cell Therapy: Encapsulated Cell Biodelivery (ECB) Systems; Introduction: Description of the Strategy; Increased Inhibition Strategies: Galanin; Neurotrophic Factors; Delivering NTF with ECB Devices; References; 6: Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions; Introduction; Dendritic Cell Subpopulations; Plasmacytoid Dendritic Cells; Conventional/Myeloid Dendritic Cells; Skin Dendritic Cells; Inflammatory DCs; Dendritic Cell Functions; Activating Signals from DCs; Inhibitory Signals from DCs.
• Publisher Details: New York, NY : Humana Press
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 615.8/4; Medicine; Cellular therapy; MEDICAL -- Pharmacology; Cellular therapy; Cell- and Tissue-Based Therapy; Medical -- Diagnostic Imaging; Medical -- Oncology; Science -- Life Sciences -- Biology -- Molecular Biology; Radiology; Oncology; Cellular biology (cytology); Pathology; Radiology, Medical; Oncology ; Cytology; Medical -- Pathology; Pathology; Electronic books
• Languages: English
• ISBNs: 9783319571539; 3319571532
• Related ISBNs: 3319571524; 9783319571522
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.