Computational methods for processing and analysis of biological pathways. ([2017])

• Record Type: Book
• Further Information: Note: Anastasios Bezerianos, Andrei Dragomir, Panso Balomenos.
• Authors: Bezerianos, Anastasios; Dragomir, Andrei; Balomenos, Panos
• Contents: Preface; Contents; 1 Introduction; Abstract; 1.1 Biological Networks; 1.1.1 Properties; 1.1.2 Categories of Biological Networks; 1.2 Pathway Analysis; 1.2.1 Methodology; 1.2.2 Evolution of Pathway Analysis Methods; 1.3 Systems Pharmacology; References; 2 Networks and Pathways in Systems Pharmacology; Abstract; 2.1 Introduction; 2.2 Network- and Pathway/Sub-pathway-Based Characterization of Drugs Mechanism of Action; 2.3 Identification of New Drug Targets and Polypharmacology Applications; 2.3.1 Target Characterization and Identification Using Network Properties of Drug Targets. 2.3.2 Identification of Drug Targets Based on Integrative Network Approaches2.3.3 Network-Based Polypharmacology; 2.4 Network-Based Drug Repositioning; 2.4.1 Drug Repositioning Based on Molecular Profiles; 2.4.2 Drug Repositioning Based on Phenotypic Profiles; 2.5 Network-Based Side Effect Modeling and Prediction; 2.5.1 Approaches Based on Chemical Structure; 2.5.2 Approaches Based on Pathways/Sub-pathways; 2.6 Current Challenges and Future Considerations; References; 3 Time-Varying Methods for Pathway and Sub-pathway Analysis; Abstract; 3.1 Introduction. 3.2 Conversion of Pathway Databases to Graphs3.3 Time-Varying Pathway and Sub-pathway Extraction; 3.3.1 Linear Sub-pathway Extraction; 3.3.2 Nonlinear Sub-pathway Extraction; 3.4 Temporal Dynamics Scoring Schemes; 3.4.1 Approach Followed in CHRONOS; 3.4.2 Other Approaches; 3.5 Synthetic and Biological Data Analysis Results; References; 4 Identification of Differentially Expressed Pathways and Sub-pathways; Abstract; 4.1 Introduction; 4.2 Approaches Based on Gene Sets; 4.3 Approaches Based on Pathway Topology; 4.4 Conversion of Pathway Databases Information to Graphs. 4.5 Gene and Pathway-Level Statistics of Differential Expression4.5.1 Methods Using Experimental Data for Sub-pathway Identification; 4.5.2 Methods Using Experimental Data for Evaluating the Statistical Significance of Sub-pathways; 4.6 DEsubs: A Flexible Tool for Identification of Differentially Expressed Sub-pathways; References.
• Publisher Details: Cham : Springer
• Publication Date: 2017
• Extent: 1 online resource (viii, 87 pages)
• Subjects: 615.19; Computer science; Drugs -- Design; Systems biology; MEDICAL -- Pharmacology; Drugs -- Design; Systems biology; Science -- Life Sciences -- General; Life sciences: general issues; Bioinformatics; Biological models; Computers -- Computer Science; Electronic books
• Languages: English
• ISBNs: 9783319538686; 3319538683
• Related ISBNs: 9783319538679; 3319538675
• Notes: Note: Includes bibliographical references.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.