Selenium. (2018)

• Record Type: Book
• Further Information: Note: Bernhard Michalke, editor.
• Editors: Michalke, Bernhard
• Contents: Intro; Editorial; Selenium; Contents; Contributors; Part I: Overview; Chapter 1: Selenium in Human Health and Disease: An Overview; Some Landmarks of Selenium Research in Human Health; Nutritional Requirements and Recommendations; The Chemical Nature of Selenium Compounds; Selenium as Part of Selenoproteins; Biomarkers of the Selenium Status; Selenium and Cancer; Selenoproteins and Cancer; Selenium in Inflammation and Immune Response; Selenium and Inflammatory Diseases; Selenium and HIV; Potential Roles of Selenoproteins in Suppressing Inflammation; Selenium and Cardiovascular Diseases Selenium and Thyroid FunctionSelenoproteins and Thyroid Function; Selenium in Male Fertility; Selenium and Diabetes; Selenoproteins and Diabetes; Conclusion; References; Part II: Bioaccessibility and Dietary Aspects of Selenium; Chapter 2: Selenium in Soils and Crops; Introduction; Selenium in Soil; Selenium Uptake and Metabolism in Crops; Biofortification of Edible Crops; References; Chapter 3: Dietary Aspects for Selenium and/or Selenium Compounds; Defining the Boundaries of Safe and Health-Supporting Se Intake; The Threat of Exaggerated Se Intake, i.e. Selenosis The Quest for Finding an Optimal Se Intake and Se StatusHealth Benefits and Limits of Optimising the Se Intake; The Path of Selenium into Our Food; Major Forms and Amount of Selenium in the Different Food Items; Fate of Selenium in the Human Body; Specific Dietary or Supplemental Se Requirements in Health and Disease; Conclusions; References; Part III: Genes, Proteins, Pathways, and Metabolism Related to Selenium; Chapter 4: Contribution of the Yeast Saccharomyces cerevisiae Model to Understand the Mechanisms of Selenium Toxicity; Introduction; Mechanisms of Inorganic Se Toxicity Selenite ToxicitySelenide Toxicity; Mechanisms of Toxicity of Selenoamino Acids; Conclusion; References; Chapter 5: Selenium Metabolism, Regulation, and Sex Differences in Mammals; Introduction; Chemical Forms and Levels of Selenium in Environment and Food Diet; Chemical Forms of Selenium Found in Living Organisms; Concentration of Selenium in the Food; Selenium Assimilation by the Body; Assimilation by the Digestive Tract; Se in the Blood and Assimilation by Different Organs; Metabolism of Selenoprotein Synthesis in the Cell; Selenocysteine-tRNA[Ser]Sec Aminoacylation Hydrogen Selenide, the Central Precursor of SelenoproteinsSelenoprotein Hierarchy; Sex Difference in Selenium Metabolism; Sex Differences in Selenoprotein Expression and Regulation; Sex-Dependent Phenotypes in Knockout Mice; Concluding Remarks; References; Part IV: The Role of Selenium within Redox Systems, Inflammation, and Thyroid Interaction; Chapter 6: Oxidative Stress, Selenium Redox Systems Including GPX/TXNRD Families; Introduction; Intrinsic Sources of ROS and Their Immediate Effects on Cellular Targets; Antioxidative Systems in Mammals
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 546.7246; Medicine; Selenium; SCIENCE / Chemistry / Inorganic; Medical -- Biochemistry; Science -- Life Sciences -- Biology -- Molecular Biology; Biochemistry; Medical research; Toxicology; Biochemistry; Medical -- Pharmacology; Pharmacology; Electronic books
• Languages: English
• ISBNs: 9783319953908; 3319953907
• Related ISBNs: 9783319953892; 3319953893
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed October 29, 2018)
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.