Pulmonary vasculature redox signaling in health and disease. (2017)

• Record Type: Book
• Further Information: Note: Yong-Xiao Wang, editor.
• Editors: Wang, Yong-Xiao
• Contents: ""Preface""; ""About the Editor""; ""Contents""; ""Contributors""; ""Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension""; ""1 Pulmonary Arterial Hypertension""; ""2 Reactive Oxygen Species, NADPH Oxidase and PAH""; ""3 Nox4 Expression in PAH""; ""4 Enzymatic Properties of Nox4""; ""5 Role of the Adventitial Fibroblast and Nox4 in PAH""; ""References""; ""Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An Important Link to Hypoxic Pulmonary Hypertension""; ""1 Introduction"" ""2 Roles of Transcription Factors in Lung Diseases""""2.1 NF-κB""; ""2.2 AP-1""; ""2.3 STAT""; ""2.4 TCF7""; ""2.5 NRF2""; ""2.6 HIF-1""; ""3 Redox-Sensitive Signaling in SMC Regulation: Role of TFs""; ""4 Conclusion and Future Perspective""; ""References""; ""Molecular Basis of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension""; ""1 Introduction""; ""2 Molecular Mechanisms of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension""; ""3 Molecular Sources of Reactive Nitrogen Species in Pulmonary Hypertension"" ""4 Molecular Sources of Reactive Oxygen Species in Pulmonary Hypertension""""5 Nitrative Stress in Pulmonary Hypertension Patients""; ""6 Conclusions""; ""References""; ""Pentose Shunt, Glucose-6-­Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension""; ""1 Pulmonary Hypertension""; ""2 Warburg Effect and Pulmonary Hypertension""; ""3 Glucose Metabolism, Pentose Shunt, and Glucose-­6-­Phosphate Dehydrogenase in Pulmonary Hypertension""; ""3.1 Glucose Metabolism is Altered in Pulmonary Hypertension"" ""3.2 Glucose-6-Phosphate Dehydrogenase Inhibition Relaxes Pulmonary Arteries, Reduces Inflammatory Cytokines and Cell Proliferation, and Induces Cell Apoptosis""""3.3 Glucose-6-Phosphate Dehydrogenase Inhibitor Treatment Reduces Pulmonary Hypertension""; ""4 G6PD and CD133 (+) Cells in Pulmonary Hypertension""; ""4.1 CD133 (+) Cells""; ""4.2 Glucose Metabolism and G6PD in CD133 (+) Cells""; ""4.3 CD133 (+) Cells Increase in Pulmonary Hypertension""; ""4.4 CD133 (+) Cells Exacerbate Pulmonary Arterial Hypertension""; ""References"" ""Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation""""1 Introduction""; ""2 The Extracellular SOD3 Enzyme""; ""2.1 Characterization of SOD3""; ""2.2 Redox Regulation of SOD3""; ""2.2.1 Intrasubunit Disulfide Bonds""; ""2.2.2 Intersubunit Disulfide Bond""; ""2.2.3 Proteolytic Cleavage of SOD3""; ""2.3 Regulation of SOD3 Activity""; ""2.4 Regulation of SOD3 Gene Expression""; ""2.5 Redox Regulation by SOD3 in Pulmonary Hypertension""; ""3 The Mitochondrial SOD2 Enzyme""; ""3.1 Characterization of SOD2""
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource (xxi, 422 pages), illustrations (some color)
• Subjects: 572/.53; Medicine; Active oxygen -- Physiological effect; Oxidation, Physiological; SCIENCE -- Life Sciences -- Biochemistry; Active oxygen -- Physiological effect; Oxidation, Physiological; Oxidation-Reduction; Signal Transduction; Humans; Medical -- Pulmonary & Thoracic Medicine; Science -- Life Sciences -- Cytology; Respiratory medicine; Cellular biology (cytology); Human physiology; Pneumology; Cell physiology; Medical -- Physiology; Physiology; Electronic books
• Languages: English
• ISBNs: 9783319632452; 3319632450
• Related ISBNs: 9783319632445; 3319632442
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed October 30, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.