MicroRNA : medical evidence from molecular biology to clinical practice /: medical evidence from molecular biology to clinical practice. ([2015])

• Record Type: Book
• Further Information: Note: Gaetano Santulli, editor.
• Editors: Santulli, Gaetano
• Contents: Foreword; Contents; Contributors; Chapter 1: Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine; References; Chapter 2: microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers; microRNA Biogenesis; microRNA Deregulation in Cancers; Specific Advantages of microRNAs in Cancer Diagnosis; Challenges in microRNA-Based Diagnosis; Conclusion; References; Chapter 3: microRNA and Pain; Introduction; miRNAs in Acute Pain; miRNAs in Neuropathic Pain: The Peripheral Nervous System. MiRNAs in Neuropathic Pain: The Spinal Cord miRNAs in Inflammation-Induced Superficial Pain; miRNAs in Arthritic Pain; miRNAs in Visceral Pain; miRNAs in Cancer Pain; miRNAs in Other Pain Conditions; Brain miRNAs in Pain Conditions; Other Noncoding RNAs in Pain; miRNA Potential for Clinical Application in Pain; References; Chapter 4: microRNA and Epilepsy; Introduction; Epilepsy; Epidemiology; Diagnosis; Treatment; Experimental Models of Epilepsy; Kainic Acid; Pilocarpine; Pentylenetetrazole; Kindling; Mechanisms Underlying Epilepsy; Genetic Mutations; Acquired Epilepsy. Neuronal Cell Loss Neuroinflammation: Microglia and Astrocyte Activation; BBB Disruption; Neuronal Plasticity; microRNAs and CNS; microRNA Biogenesis and Mechanisms of Action; miRNAs Regulate Key Processes in Epilepsy; miRNA Profiling in Status Epilepticus and Epilepsy; Molecular Mechanisms of miRNA Expression Control in Epilepsy; miRNA and Epilepsy: An Overview About Functional Studies; miRNA as Biomarkers of Epilepsy; Conclusion; References; Chapter 5: microRNA and Autism; Introduction; Genetic Architecture of Autism Is Complex; microRNAs in Neurodevelopment; Circulating miRNAs. MiRNAs in Neurological Disorders miRNAs in Autism; Therapeutic Potential of miRNAs; Future Directions; References; Chapter 6: microRNAs and Neurodegenerative Diseases; Introduction; miRNA in Neurodegenerative Diseases; miRNAs and AD; Dysregulation of miRNA in AD; miR-9 in AD; miR-29 in AD; miRNA let-7b in AD; miR-106b in AD; miRNAs and PD; Dysregulation of miRNA in PD; miR-133b in PD; miR-107 in PD; miR-34 in PD; miR-205 in PD; miRNAs and HD; Dysregulated miRNA in HD; miR-9 in HD; miR-22 in HD; miR-128 in HD; miR-132 in HD; miRNAs and ALS; Dysregulated miRNA in ALS. MiR-206 in ALSmiR-155 in ALS; Therapeutic Potential of miRNAs in Neurodegenerative Diseases; Development of miRNA-Based Therapeutics; Development of Anti-microRNA-Based Therapeutics; Antisense Oligonucleotides; Antagomirs; miRNA Sponge; Locked Nucleic Acid; Development of miRNA Biogenesis-Based Therapeutics; Challenge of Delivering Therapeutic miRNA Targets in NDDs; Crossing the BBB to Deliver Therapeutics miRNA Targets; Exosome; Non-viral; Viral; Toxicity and Off-Target Effects of Delivering Therapeutic miRNA Targets; Conclusion; References; Chapter 7: microRNAs and Fragile X Syndrome.
• Publisher Details: Cham : Springer International Publishing
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (xii, 429 pages)
• Subjects: 572.8/8; 572.865; Medicine; Small interfering RNA; SCIENCE -- Life Sciences -- Biochemistry; Small interfering RNA; Science -- Life Sciences -- Cytology; Science -- Molecular Physics; Medical -- Physiology; Cellular biology (cytology); Nuclear physics; Zoology & animal sciences; Physiology; Cell physiology; Biochemistry; Human physiology; Science -- Life Sciences -- Biology -- Molecular Biology; Medical research; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319226712; 3319226711; 3319226703; 9783319226705
• Related ISBNs: 9783319226705
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed December 17, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.