The genetics and development of scoliosis. ([2018])

• Record Type: Book
• Further Information: Note: Kenro Kusumi, Sally L. Dunwoodie, editors.
• Editors: Kusumi, Kenro; Dunwoodie, Sally L
• Contents: Intro; Dedication; Preface; Contents; Contributors; Chapter 1: Developmental andFunctional Anatomy oftheSpine; Introduction; Embryonic Origins oftheSpine; Establishing theIntersomitic Boundary; Somite Epithelialization; Rostral/Caudal Polarity ofSomites; The Anatomy andDevelopment oftheVertebrae andIntervertebral Discs; Functional Anatomy oftheVertebrae andIV Discs; Development oftheVertebrae; Rostral/Caudal Patterning; Formation oftheIV Discs; The Anatomy andDevelopment ofSpinal Muscles; Functional Anatomy oftheSpinal Muscles; Development ofSpinal Muscles Tendon DevelopmentSummary; References; Chapter 2: Environmental Factors andAxial Skeletal Dysmorphogenesis; Introduction; Vertebral Dysmorphogenesis inHuman Congenital Scoliosis; Normal Development oftheAxial Skeleton; Experimental Axial Skeletal Teratology; Pathogenesis ofAbnormal Axial Development; Overview ofAgents andConditions Associated withAxial Skeletal Teratogenesis; Recreational Teratogens; Pharmaceutical Teratogens; Industrial andEnvironmental Teratogens; Agricultural Teratogens; Infectious Diseases; Metabolic Conditions Nongenetically Linked Conditions Characterized byAxial Skeletal DefectsSpina Bifida; The VATER Association; Environmental Factors That Cause Axial Skeletal Dysmorphogenesis; Valproic Acid; Hypoxia; Carbon Monoxide; Diabetes; Retinoic Acid; Hyperthermia; Arsenic; Ethanol; Methanol; Conclusion; References; Chapter 3: Congenital Scoliosis andSegmentation Defects oftheVertebrae intheGenetic Clinic; Introduction; Spondylocostal Dysostosis, Somitogenesis, andtheNotch Signalling Pathway; Varied Use ofClinical Terminology; Spondylocostal Dysostosis; Klippel-Feil Syndrome The Genetics andClinical Description ofSCD SubtypesSCD1; SCD2; STD: Spondylothoracic Dysostosis; SCD3; SCD4; SCD5: Autosomal Dominant; SCD6; TBX6, Congenital Scoliosis, andMURCS; A New Classification andRadiological Reporting System forSDV; References; Chapter 4: The Genetics Contributing toDisorders Involving Congenital Scoliosis; Introduction; Background; Embryological Basis ofCS; Approaches inUnderstanding theGenetic Etiology ofCS; TBX6 Variants Contributing toCS; Syndromes andDisorders Associated withVMs; Spondylocostal Dysostosis; Klippel-Feil Syndrome Syndromes Containing CS PhenotypeAlagille Syndrome; VACTERL Association; Congenital NAD Deficiency Disorders; Facio-Auriculo-Vertebral Spectrum; Perspective; References; Chapter 5: Animal Models ofIdiopathic Scoliosis; Introduction; Normal Spine Function Requires theIntegration ofMultiple Musculoskeletal Tissues; Spine Form Follows Dysfunction; What Makes aGood Animal Model ofDisease?; Animal Models; Mechanical Models ofIS; Environmental Models; Genetic/Heritable Models ofIS; Aquatic Models ofIS; Mouse Models; Distinct Elements oftheMammalian Spine
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.73042; Medicine; Scoliosis -- Genetic aspects; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Biomedicine; Human Genetics; Developmental Biology; Human Physiology; Orthopedics; Science -- Life Sciences -- Biology -- Developmental Biology; Medical -- Physiology; Medical -- Orthopedics; Developmental biology; Physiology; Orthopaedics & fractures; Human genetics; Developmental biology; Human physiology; Orthopedics; Medical -- Genetics; Medical genetics; Electronic books
• Languages: English
• ISBNs: 9783319901497; 3319901494; 3319901486; 9783319901480
• Related ISBNs: 9783319901480
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed June 19, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.